FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W240486347> ?p ?o ?g. }

• W240486347 abstract "Chronic obstructive pulmonary disease (COPD) is defined by irreversible airflow limitation, usually caused by exposure to noxious particles or gases. COPD patients suffer from chronic daily symptoms, and may occasionally suffer acute exacerbations – episodes in which there is a worsening of symptoms above day-today levels. Exacerbation aetiology is variable and controversial, although infection and air pollution are believed to play a part. Certain bacterial pathogens, known as typical airway bacteria, are found with high prevalence in individuals at exacerbation. The burden of other airway bacteria is currently ill-defined. This study initially compared microbiological culture with quantitative PCR for detection of three commonly identified airway bacteria in COPD, Haemophilus influenzae, Streptococcus pneumoniae, Moraxella catarrhalis (typical airway bacteria). Quantitative PCR was utilised to establish prevalence and load of these species at stable, exacerbation and exacerbation recovery states. Typical airway bacterial prevalence and load was assessed against a range of clinical factors in COPD. Additional quantitative PCRs examined the prevalence and load of atypical airway bacteria (Chlamydophila pneumoniae, Legionella pneumophila, Mycoplasma pneumoniae) and the entire bacterial microflora of the lungs. My original contribution to knowledge is that higher load of typical airway bacteria is associated with higher levels of systemic inflammation and airflow limitation in both stable and exacerbated COPD. For the first time it has also been demonstrated that airway microbiome load is not associated with airflow limitation or systemic inflammation changes, providing evidence that typical airway bacteria in particular are contributing to disease severity. Atypical airway bacteria prevalence in COPD was negligible. The investigations in this thesis highlight the need for rapid antibiotic therapy in exacerbations where typical airway bacteria presence is suspected or confirmed. Furthermore, prophylactic antibiotic therapy should be considered for stable COPD patients with confirmed typical airway bacterial presence, as a means of reducing inflammation and airflow limitation." @default.
• W240486347 created "2016-06-24" @default.
• W240486347 creator A5064516492 @default.
• W240486347 date "2014-04-28" @default.
• W240486347 modified "2023-09-25" @default.
• W240486347 title "Prevalence and load of airway bacteria in chronic obstructive pulmonary disease" @default.
• W240486347 cites W1221909616 @default.
• W240486347 cites W1486340853 @default.
• W240486347 cites W1531737953 @default.
• W240486347 cites W155921487 @default.
• W240486347 cites W1598255190 @default.
• W240486347 cites W1669463052 @default.
• W240486347 cites W1760281680 @default.
• W240486347 cites W1772212485 @default.
• W240486347 cites W1856169132 @default.
• W240486347 cites W1879948240 @default.
• W240486347 cites W1895102180 @default.
• W240486347 cites W1941094264 @default.
• W240486347 cites W1941596385 @default.
• W240486347 cites W1948307823 @default.
• W240486347 cites W1963723016 @default.
• W240486347 cites W1965294032 @default.
• W240486347 cites W1969607968 @default.
• W240486347 cites W1970249744 @default.
• W240486347 cites W1973998064 @default.
• W240486347 cites W1975959231 @default.
• W240486347 cites W1978053634 @default.
• W240486347 cites W1978892575 @default.
• W240486347 cites W1982140654 @default.
• W240486347 cites W1984454286 @default.
• W240486347 cites W1985599412 @default.
• W240486347 cites W1985644458 @default.
• W240486347 cites W1986780776 @default.
• W240486347 cites W1986805358 @default.
• W240486347 cites W1988561270 @default.
• W240486347 cites W1989362179 @default.
• W240486347 cites W1989424168 @default.
• W240486347 cites W1989511322 @default.
• W240486347 cites W1989877439 @default.
• W240486347 cites W1989939103 @default.
• W240486347 cites W1990866025 @default.
• W240486347 cites W1991194951 @default.
• W240486347 cites W1991648511 @default.
• W240486347 cites W1994169274 @default.
• W240486347 cites W1999226863 @default.
• W240486347 cites W1999399962 @default.
• W240486347 cites W2000589759 @default.
• W240486347 cites W2000802816 @default.
• W240486347 cites W2001827876 @default.
• W240486347 cites W2002438168 @default.
• W240486347 cites W2004748855 @default.
• W240486347 cites W2006319950 @default.
• W240486347 cites W2006860411 @default.
• W240486347 cites W2007794367 @default.
• W240486347 cites W2008212067 @default.
• W240486347 cites W2008710087 @default.
• W240486347 cites W2010967671 @default.
• W240486347 cites W2012519534 @default.
• W240486347 cites W2012556907 @default.
• W240486347 cites W2013065585 @default.
• W240486347 cites W2015070045 @default.
• W240486347 cites W2015869947 @default.
• W240486347 cites W2017383182 @default.
• W240486347 cites W2017821807 @default.
• W240486347 cites W2021387811 @default.
• W240486347 cites W2025900894 @default.
• W240486347 cites W2026295592 @default.
• W240486347 cites W2026667514 @default.
• W240486347 cites W2029965213 @default.
• W240486347 cites W2031308271 @default.
• W240486347 cites W2031679199 @default.
• W240486347 cites W2032166498 @default.
• W240486347 cites W2034749517 @default.
• W240486347 cites W2035756448 @default.
• W240486347 cites W2036395412 @default.
• W240486347 cites W2037630777 @default.
• W240486347 cites W2039487466 @default.
• W240486347 cites W2039768835 @default.
• W240486347 cites W2040539560 @default.
• W240486347 cites W2041902804 @default.
• W240486347 cites W2041966581 @default.
• W240486347 cites W2045195138 @default.
• W240486347 cites W2050505650 @default.
• W240486347 cites W2050591900 @default.
• W240486347 cites W2050682307 @default.
• W240486347 cites W2053463673 @default.
• W240486347 cites W2054316293 @default.
• W240486347 cites W2055753580 @default.
• W240486347 cites W2057386959 @default.
• W240486347 cites W2061693875 @default.
• W240486347 cites W2067827123 @default.
• W240486347 cites W2068234766 @default.
• W240486347 cites W2068332307 @default.
• W240486347 cites W2069484087 @default.
• W240486347 cites W2070429561 @default.
• W240486347 cites W2071093148 @default.
• W240486347 cites W2074612698 @default.
• W240486347 cites W2076125518 @default.
• W240486347 cites W2076168952 @default.
• W240486347 cites W2077691383 @default.

• next