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- W2404863485 abstract "Growth factors are of great potential in regenerative medicine. However, their clinical applications are largely limited by the short in vivo half-lives and the narrow therapeutic window. Thus, a robust controlled release system remains an unmet medical need for growth-factor-based therapies. In this research, a nanoscale controlled release system (degradable protein nanocapsule) is established via in situ polymerization on growth factor. The release rate can be finely tuned by engineering the surface polymer composition. Improved therapeutic outcomes can be achieved with growth factor nanocapsules, as illustrated in spinal cord fusion mediated by bone morphogenetic protein-2 nanocapsules." @default.
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- W2404863485 date "2016-07-19" @default.
- W2404863485 modified "2023-10-02" @default.
- W2404863485 title "Growth-Factor Nanocapsules That Enable Tunable Controlled Release for Bone Regeneration" @default.
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- W2404863485 doi "https://doi.org/10.1021/acsnano.5b07950" @default.
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