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- W2404893313 abstract "Voltage-gated potassium channels (Kv4.1, Kv4.2 and Kv4.3) encoded by the members of the KCND/Kv4 (Shal) channel family mediate the native, fast inactivating (A-type) K(+) current (IA) described both in heart and neurons. This IA current is specifically blocked by short scorpion toxins that belong to the α-KTx15 subfamily and which act as pore blockers, a different mode of action by comparison to spider toxins known as gating modifiers. This review summarizes our present chemical and pharmacological knowledge on the α-KTx15 toxins." @default.
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- W2404893313 date "2015-06-25" @default.
- W2404893313 modified "2023-10-03" @default.
- W2404893313 title "Shal-type (Kv4.x) potassium channel pore blockers from scorpion venoms." @default.
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