FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2405074920> ?p ?o ?g. }

• W2405074920 abstract "Macular pigment (MP) has been related to the occurrence of age related macular degeneration (AMD). We investigated prospectively in eyes of elderly individuals how magnitude and spatial distribution of MP had changed after 4 years. The study included 380 eyes from 237 participants of the Münster Ageing and Retina Study cohort which were free of advanced stages of AMD. MP optical density (MPOD) was measured in density units (D.U.) at eccentricities of 0.25°, 0.5°, 1.0° and 2.0° from the fovea using dual-wavelength autofluorescence; ring-like MP distributions were identified from MP density profiles. Changes were assessed with mixed linear models. The study participants’ mean age at baseline was 70.5 years. Early AMD was present in 150 study eyes (39.5 %) and a ring-like distribution of MPOD was found in 87 study eyes (22.9 %). After a median follow-up time of 3.96 years, the MPOD averaged over all eyes was slightly raised at the central fovea (from 0.658 to 0.670 D.U. (relative change +1.8 %), p = 0.08) and most markedly at 2.0° (from 0.157 to 0.172 D.U. (+9.5 %), p < 0.001). Multivariate analyses, adjusting for sex, body mass and carotenoid supplement intake, revealed that MPOD increments, at any distance from the fovea, were slightly less pronounced in older eyes. Serum concentrations of lutein at follow-up, presumably reflecting recent intake of antioxidant supplements, raised MPOD levels significantly at 1.0° and 2.0° (both p < 0.01) but not in the central fovea. Early AMD at baseline and ring-like MPOD distribution did not significantly impact on MPOD changes over time. A ring-like spatial distribution of MPOD persisted in over 80 % of the affected eyes. Overall, the magnitude and spatial arrangement of MPOD was remarkably stable over time in elderly eyes. Significant MPOD rises in perifoveal regions probably indicate effects of lutein containing supplements. The persistence of ring-like MPOD distributions over time seems to suggest their determination by anatomical structures." @default.
• W2405074920 created "2016-06-24" @default.
• W2405074920 creator A5012537661 @default.
• W2405074920 creator A5031797997 @default.
• W2405074920 creator A5047562697 @default.
• W2405074920 creator A5052441348 @default.
• W2405074920 creator A5065946805 @default.
• W2405074920 date "2016-06-01" @default.
• W2405074920 modified "2023-10-17" @default.
• W2405074920 title "Changes of macular pigment optical density in elderly eyes: a longitudinal analysis from the MARS study" @default.
• W2405074920 cites W1214309681 @default.
• W2405074920 cites W151625338 @default.
• W2405074920 cites W1555915176 @default.
• W2405074920 cites W1895408795 @default.
• W2405074920 cites W1968549735 @default.
• W2405074920 cites W1976489026 @default.
• W2405074920 cites W1995106230 @default.
• W2405074920 cites W2007242534 @default.
• W2405074920 cites W2007715642 @default.
• W2405074920 cites W2008088358 @default.
• W2405074920 cites W2012845790 @default.
• W2405074920 cites W2025300199 @default.
• W2405074920 cites W2030526498 @default.
• W2405074920 cites W2039574071 @default.
• W2405074920 cites W2047010106 @default.
• W2405074920 cites W2067707240 @default.
• W2405074920 cites W2068788088 @default.
• W2405074920 cites W2073969162 @default.
• W2405074920 cites W2076600499 @default.
• W2405074920 cites W2078121298 @default.
• W2405074920 cites W2078761299 @default.
• W2405074920 cites W2088397282 @default.
• W2405074920 cites W2093884863 @default.
• W2405074920 cites W2140893028 @default.
• W2405074920 cites W2151187735 @default.
• W2405074920 cites W2158770960 @default.
• W2405074920 cites W2166175175 @default.
• W2405074920 doi "https://doi.org/10.1186/s40942-016-0039-6" @default.
• W2405074920 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5088485" @default.
• W2405074920 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27847632" @default.
• W2405074920 hasPublicationYear "2016" @default.
• W2405074920 type Work @default.
• W2405074920 sameAs 2405074920 @default.
• W2405074920 citedByCount "7" @default.
• W2405074920 countsByYear W24050749202017 @default.
• W2405074920 countsByYear W24050749202020 @default.
• W2405074920 countsByYear W24050749202021 @default.
• W2405074920 countsByYear W24050749202022 @default.
• W2405074920 countsByYear W24050749202023 @default.
• W2405074920 crossrefType "journal-article" @default.
• W2405074920 hasAuthorship W2405074920A5012537661 @default.
• W2405074920 hasAuthorship W2405074920A5031797997 @default.
• W2405074920 hasAuthorship W2405074920A5047562697 @default.
• W2405074920 hasAuthorship W2405074920A5052441348 @default.
• W2405074920 hasAuthorship W2405074920A5065946805 @default.
• W2405074920 hasBestOaLocation W24050749201 @default.
• W2405074920 hasConcept C118487528 @default.
• W2405074920 hasConcept C126322002 @default.
• W2405074920 hasConcept C185592680 @default.
• W2405074920 hasConcept C188816634 @default.
• W2405074920 hasConcept C2776403814 @default.
• W2405074920 hasConcept C2778411929 @default.
• W2405074920 hasConcept C28781525 @default.
• W2405074920 hasConcept C3020486325 @default.
• W2405074920 hasConcept C31903555 @default.
• W2405074920 hasConcept C71924100 @default.
• W2405074920 hasConcept C72563966 @default.
• W2405074920 hasConceptScore W2405074920C118487528 @default.
• W2405074920 hasConceptScore W2405074920C126322002 @default.
• W2405074920 hasConceptScore W2405074920C185592680 @default.
• W2405074920 hasConceptScore W2405074920C188816634 @default.
• W2405074920 hasConceptScore W2405074920C2776403814 @default.
• W2405074920 hasConceptScore W2405074920C2778411929 @default.
• W2405074920 hasConceptScore W2405074920C28781525 @default.
• W2405074920 hasConceptScore W2405074920C3020486325 @default.
• W2405074920 hasConceptScore W2405074920C31903555 @default.
• W2405074920 hasConceptScore W2405074920C71924100 @default.
• W2405074920 hasConceptScore W2405074920C72563966 @default.
• W2405074920 hasFunder F4320320879 @default.
• W2405074920 hasIssue "1" @default.
• W2405074920 hasLocation W24050749201 @default.
• W2405074920 hasLocation W24050749202 @default.
• W2405074920 hasLocation W24050749203 @default.
• W2405074920 hasLocation W24050749204 @default.
• W2405074920 hasOpenAccess W2405074920 @default.
• W2405074920 hasPrimaryLocation W24050749201 @default.
• W2405074920 hasRelatedWork W1197643255 @default.
• W2405074920 hasRelatedWork W1976597957 @default.
• W2405074920 hasRelatedWork W2031754114 @default.
• W2405074920 hasRelatedWork W2035206720 @default.
• W2405074920 hasRelatedWork W2076931386 @default.
• W2405074920 hasRelatedWork W2155895895 @default.
• W2405074920 hasRelatedWork W2156729593 @default.
• W2405074920 hasRelatedWork W2183950631 @default.
• W2405074920 hasRelatedWork W2598273072 @default.
• W2405074920 hasRelatedWork W3028643654 @default.
• W2405074920 hasVolume "2" @default.
• W2405074920 isParatext "false" @default.
• W2405074920 isRetracted "false" @default.
• W2405074920 magId "2405074920" @default.

• next