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• W2405102490 abstract "Podosomes are dynamic cell-matrix contact structures that combine several key abilities, including adhesion, matrix degradation and mechanosensing. These actin-based cytoskeletal structures are well known in monocytic cells, but much less is known about those formed in other lineages. In this study, we characterize podosomes in capillary-derived microvascular endothelial cells. We identify two types of podosomes: constitutive podosomes that form in the absence of specific stimulation and induced podosomes that arise in response to the angiogenic factor VEGF-A. Constitutive and VEGF-A-induced podosomes share similar components but exhibit marked differences in terms of gelatinolytic activity. We also show that extracellular matrix proteins are key determinants of the VEGF-A response: laminin and collagen-IV, but neither collagen-I nor fibronectin are conducive for podosome induction. Moreover, only collagen-IV elicits the formation of proteolytically active podosomes through a mechanism involving increased Src phosphorylation, p190RhoGAP-B relocalisation and MT1-MMP cell surface exposure at podosome sites. We hypothesise that by promoting podosome formation, VEGF-A enables endothelial cells to overcome the basement membrane barrier for sprouting away from the existing vasculature." @default.
• W2405102490 created "2016-06-24" @default.
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• W2405102490 date "2016-01-01" @default.
• W2405102490 modified "2023-09-27" @default.
• W2405102490 title "VEGF-A stimulates podosome-mediated collagen-IV proteolysis in microvascular endothelial cells" @default.
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• W2405102490 doi "https://doi.org/10.1242/jcs.186585" @default.
• W2405102490 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27231093" @default.
• W2405102490 hasPublicationYear "2016" @default.
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