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• W2405129084 startingPage "114" @default.
• W2405129084 abstract "D ERANGEMENTS in divalent ion metabolism is commonly encountered in patients with renal failure. im7 Table 1 lists the various manifestations of these abnormalities. The disturbances in divalent ion metabolism appear early in the course of renal insufficiency and worsen as renal failure progresses. L-7 Therefore, the approach to the management of these abnormalities should include measures to prevent their progression and therapeutic modalities to treat those that are already established. The overall goals of the therapeutic approach are: (1) to maintain the blood levels of calcium and phosphorus as near normal as possible, (2) to prevent the development of secondary hyperparathyroidism, and, if the latter already exists, to suppress the activity of the parathyroid glands, (3) to prevent and reverse bone disease, (4) to prevent and reverse soft tissue calcification, and (5) to ameliorate or reverse proximal myopathy, bone pain, pruritus, and soft tissue necrosis. The therapeutic modalities that are currently being utilized in the treatment of the derangements of divalent ion metabolism include: (1) supplementation of calcium, (2) dietary phosphate restriction and the use of phosphate binding antacids, (3) administration of vitamin D or its metabolites, (4) appropriate dialysis composition in the dialysis patients, (5) chelation of aluminum in those with increased aluminum burden, and (6) parathyroidectomy." @default.
• W2405129084 created "2016-06-24" @default.
• W2405129084 creator A5063237643 @default.
• W2405129084 date "1986-06-01" @default.
• W2405129084 modified "2023-09-23" @default.
• W2405129084 title "Prevention and treatment of the abnormalities in divalent ion metabolism in renal failure." @default.
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• W2405129084 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3303238" @default.
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