Matches in SemOpenAlex for { <https://semopenalex.org/work/W2405133609> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2405133609 endingPage "6872" @default.
- W2405133609 startingPage "6865" @default.
- W2405133609 abstract "The OECD guidelines 308 and 309 define simulation tests aimed at assessing biotransformation of chemicals in water-sediment systems. They should serve the estimation of persistence indicators for hazard assessment and half-lives for exposure modeling. Although dissipation half-lives of the parent compound are directly extractable from OECD 308 data, they are system-specific and mix up phase transfer with biotransformation. In contrast, aerobic biotransformation half-lives should be easier to extract from OECD 309 experiments with suspended sediments. Therefore, there is scope for OECD 309 tests with suspended sediment to serve as a proxy for degradation in the aerobic phase of the more complicated OECD 308 test, but that correspondence has remained untested so far. Our aim was to find a way to extract biotransformation rate constants that are universally valid across variants of water-sediment systems and, hence, provide a more general description of the compound’s behavior in the environment. We developed a unified model that was able to simulate four experimental types (two variants of OECD 308 and two variants of OECD 309) for three compounds by using a biomass-corrected, generalized aerobic biotransformation parameter (k′bio). We used Bayesian calibration and uncertainty assessment to calibrate the models for individual experimental types separately and for combinations of experimental types. The results suggested that k′bio was a generally valid parameter for quantifying biotransformation across systems. However, its uncertainty remained significant when calibrated on individual systems alone. Using at least two different experimental types for the calibration of k′bio increased its robustness by clearly separating degradation from the phase-transfer processes taking place in the individual systems. Overall, k′bio has the potential to serve as a system-independent descriptor of aerobic biotransformation at the water–sediment interface that is equally and consistently applicable for both persistence and exposure assessment purposes." @default.
- W2405133609 created "2016-06-24" @default.
- W2405133609 creator A5008525898 @default.
- W2405133609 creator A5020202476 @default.
- W2405133609 creator A5036265356 @default.
- W2405133609 creator A5044405346 @default.
- W2405133609 creator A5051193417 @default.
- W2405133609 creator A5062066278 @default.
- W2405133609 date "2016-06-14" @default.
- W2405133609 modified "2023-10-14" @default.
- W2405133609 title "Bridging across OECD 308 and 309 Data in Search of a Robust Biotransformation Indicator" @default.
- W2405133609 cites W1977065472 @default.
- W2405133609 cites W1992301911 @default.
- W2405133609 cites W2016435780 @default.
- W2405133609 cites W2045640984 @default.
- W2405133609 cites W2066593862 @default.
- W2405133609 cites W2073727931 @default.
- W2405133609 cites W2168175751 @default.
- W2405133609 cites W2284069898 @default.
- W2405133609 cites W2291317177 @default.
- W2405133609 cites W2468878421 @default.
- W2405133609 doi "https://doi.org/10.1021/acs.est.6b01097" @default.
- W2405133609 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27213716" @default.
- W2405133609 hasPublicationYear "2016" @default.
- W2405133609 type Work @default.
- W2405133609 sameAs 2405133609 @default.
- W2405133609 citedByCount "30" @default.
- W2405133609 countsByYear W24051336092016 @default.
- W2405133609 countsByYear W24051336092017 @default.
- W2405133609 countsByYear W24051336092018 @default.
- W2405133609 countsByYear W24051336092019 @default.
- W2405133609 countsByYear W24051336092020 @default.
- W2405133609 countsByYear W24051336092021 @default.
- W2405133609 countsByYear W24051336092022 @default.
- W2405133609 countsByYear W24051336092023 @default.
- W2405133609 crossrefType "journal-article" @default.
- W2405133609 hasAuthorship W2405133609A5008525898 @default.
- W2405133609 hasAuthorship W2405133609A5020202476 @default.
- W2405133609 hasAuthorship W2405133609A5036265356 @default.
- W2405133609 hasAuthorship W2405133609A5044405346 @default.
- W2405133609 hasAuthorship W2405133609A5051193417 @default.
- W2405133609 hasAuthorship W2405133609A5062066278 @default.
- W2405133609 hasConcept C105795698 @default.
- W2405133609 hasConcept C107872376 @default.
- W2405133609 hasConcept C127413603 @default.
- W2405133609 hasConcept C151730666 @default.
- W2405133609 hasConcept C165838908 @default.
- W2405133609 hasConcept C181199279 @default.
- W2405133609 hasConcept C183696295 @default.
- W2405133609 hasConcept C185592680 @default.
- W2405133609 hasConcept C186060115 @default.
- W2405133609 hasConcept C27881333 @default.
- W2405133609 hasConcept C2816523 @default.
- W2405133609 hasConcept C33923547 @default.
- W2405133609 hasConcept C39432304 @default.
- W2405133609 hasConcept C55493867 @default.
- W2405133609 hasConcept C86803240 @default.
- W2405133609 hasConceptScore W2405133609C105795698 @default.
- W2405133609 hasConceptScore W2405133609C107872376 @default.
- W2405133609 hasConceptScore W2405133609C127413603 @default.
- W2405133609 hasConceptScore W2405133609C151730666 @default.
- W2405133609 hasConceptScore W2405133609C165838908 @default.
- W2405133609 hasConceptScore W2405133609C181199279 @default.
- W2405133609 hasConceptScore W2405133609C183696295 @default.
- W2405133609 hasConceptScore W2405133609C185592680 @default.
- W2405133609 hasConceptScore W2405133609C186060115 @default.
- W2405133609 hasConceptScore W2405133609C27881333 @default.
- W2405133609 hasConceptScore W2405133609C2816523 @default.
- W2405133609 hasConceptScore W2405133609C33923547 @default.
- W2405133609 hasConceptScore W2405133609C39432304 @default.
- W2405133609 hasConceptScore W2405133609C55493867 @default.
- W2405133609 hasConceptScore W2405133609C86803240 @default.
- W2405133609 hasIssue "13" @default.
- W2405133609 hasLocation W24051336091 @default.
- W2405133609 hasLocation W24051336092 @default.
- W2405133609 hasOpenAccess W2405133609 @default.
- W2405133609 hasPrimaryLocation W24051336091 @default.
- W2405133609 hasRelatedWork W191562529 @default.
- W2405133609 hasRelatedWork W2015972624 @default.
- W2405133609 hasRelatedWork W2079027353 @default.
- W2405133609 hasRelatedWork W2092336730 @default.
- W2405133609 hasRelatedWork W2143021045 @default.
- W2405133609 hasRelatedWork W2416210287 @default.
- W2405133609 hasRelatedWork W2551357364 @default.
- W2405133609 hasRelatedWork W2899084033 @default.
- W2405133609 hasRelatedWork W2902459209 @default.
- W2405133609 hasRelatedWork W4311364212 @default.
- W2405133609 hasVolume "50" @default.
- W2405133609 isParatext "false" @default.
- W2405133609 isRetracted "false" @default.
- W2405133609 magId "2405133609" @default.
- W2405133609 workType "article" @default.