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- W2405152007 abstract "493 Objectives The utility of PET in preclinical research is limited by spatial resolution and signal-to-noise ratio of the images. A recently developed PET system uses a clustered-pinhole collimator, enabling high-resolution, simultaneous imaging of PET and SPECT tracers. We investigated the potential of this design by direct comparison with a traditional PET scanner. Methods Two small animal PET scanners, one with electronic collimation (Siemens Focus120) and one with physical collimation using clustered pinholes (MILabs VECTor), were used to acquire data from Jaszczak and uniform phantoms. Mouse brain imaging using [18F]FDG PET was performed alongside quantitative ex-vivo autoradiography for reference. Bone imaging using [18F]NaF allowed comparison of imaging in the mouse body. Images were visually and quantitatively compared using measures of contrast and noise. Results Pinhole PET resolved the smallest rods (0.85 mm diameter) in the Jaszczak phantom, while coincidence PET resolved 1.1 mm diameter rods. Contrast-to-noise ratios were better for pinhole PET when imaging small rods ( Conclusions When small regions need to be resolved in scans with reasonably high activity or reasonably long scan times, a first generation clustered-pinhole system can provide superior image quality in terms of resolution, contrast and the contrast-to-noise ratio as compared to a traditional PET system. Research Support Canadian Institutes of Health Research, Pieken in de Delta grant PID06015, the Canadian Foundation for Innovation, the BC Knowledge Development Fund and the Natural Sciences and Engineering Research Council of Canada." @default.
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- W2405152007 date "2014-05-01" @default.
- W2405152007 modified "2023-10-06" @default.
- W2405152007 title "Comparison of preclinical PET scanners: Pinhole collimation vs. electronic collimation" @default.
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