FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2405247265> ?p ?o ?g. }

• W2405247265 endingPage "1469" @default.
• W2405247265 startingPage "1461" @default.
• W2405247265 abstract "Abstract We report here experiments on the analysis of cellular signal transduction in a series of patients with chronic B cell disorders (B cell chronic lymphocytic leukemia [B-CLL] and prolymphocytic leukemia). We compared the response of the leukemic cells with primary external signals (interleukin 2 [IL-2] or B cell differentiation factors [BCDF or IL-6]) with their response to secondary inducers (the phorbol ester (12–O-tetradecanoylphorbol-13-acetate [TPA] or the calcium ionophore A23187) that circumvent the first part of the signal transduction pathway by directly activating the key enzyme protein kinase C. One BCDF was synthesized by mitogen-activated peripheral blood B lymphocytes; a second BCDF was constitutively produced by the human bladder carcinoma cell line T24. Changes in morphology, Tac (IL-2 receptor) expression, RNA synthesis measured by 3H-uridine uptake, and immunoglobulin production tested by enzyme-linked immunosorbent assay were used as parameters of successful signal transduction. TPA alone and TPA plus A23187 (synergistically) effectively initiated differentiation in all the leukemia cases. Neither IL-2 nor BCDF (singly or in combinations) caused equivalent responses. On the other hand, IL-2 and BCDF produced a substantial differentiation effect on normal B lymphocytes. Our data suggest that (a) B-CLL cells are able to respond to direct stimulation of the second messenger pathway (through protein kinase C) but not to the physiological stimuli IL-2 or BCDF; (b) the defect in signal transduction appears to be located upstream of protein kinase C (a possible candidate is a G protein); (c) malignant B cells may spontaneously or after treatment with inducers express the IL- 2 receptor (Tac antigen) in the absence of a functional differentiating response to IL-2; and (d) signs of proliferation/differentiation in B- CLL samples after incubation with IL-2 or BCDF might be due to contamination of the cell populations with residual normal B cells." @default.
• W2405247265 created "2016-06-24" @default.
• W2405247265 creator A5037616829 @default.
• W2405247265 creator A5041495085 @default.
• W2405247265 creator A5058287032 @default.
• W2405247265 creator A5061926072 @default.
• W2405247265 creator A5063892070 @default.
• W2405247265 date "1988-05-01" @default.
• W2405247265 modified "2023-10-07" @default.
• W2405247265 title "Analysis of signal transduction in B chronic lymphocytic leukemia cells" @default.
• W2405247265 cites W1483547175 @default.
• W2405247265 cites W1491459289 @default.
• W2405247265 cites W1541120704 @default.
• W2405247265 cites W1549769415 @default.
• W2405247265 cites W1560105324 @default.
• W2405247265 cites W1574528637 @default.
• W2405247265 cites W17958589 @default.
• W2405247265 cites W1807044881 @default.
• W2405247265 cites W1965761745 @default.
• W2405247265 cites W1965819694 @default.
• W2405247265 cites W1971353726 @default.
• W2405247265 cites W1973237558 @default.
• W2405247265 cites W1976038149 @default.
• W2405247265 cites W1978274173 @default.
• W2405247265 cites W1980673569 @default.
• W2405247265 cites W1981319123 @default.
• W2405247265 cites W1995541525 @default.
• W2405247265 cites W1995680590 @default.
• W2405247265 cites W2001692359 @default.
• W2405247265 cites W2002076761 @default.
• W2405247265 cites W2004654501 @default.
• W2405247265 cites W2008295169 @default.
• W2405247265 cites W2010001741 @default.
• W2405247265 cites W2014555925 @default.
• W2405247265 cites W2016478177 @default.
• W2405247265 cites W2018128697 @default.
• W2405247265 cites W2023023900 @default.
• W2405247265 cites W2026108503 @default.
• W2405247265 cites W2026157738 @default.
• W2405247265 cites W2026818401 @default.
• W2405247265 cites W2027527881 @default.
• W2405247265 cites W2031062533 @default.
• W2405247265 cites W2035304994 @default.
• W2405247265 cites W2041624016 @default.
• W2405247265 cites W2041630907 @default.
• W2405247265 cites W2045534262 @default.
• W2405247265 cites W2048375356 @default.
• W2405247265 cites W2051109968 @default.
• W2405247265 cites W2064265012 @default.
• W2405247265 cites W2068877244 @default.
• W2405247265 cites W2087167407 @default.
• W2405247265 cites W2092839821 @default.
• W2405247265 cites W2116360471 @default.
• W2405247265 cites W2122216009 @default.
• W2405247265 cites W2124869079 @default.
• W2405247265 cites W2126486896 @default.
• W2405247265 cites W2155826396 @default.
• W2405247265 cites W226094559 @default.
• W2405247265 cites W2336483523 @default.
• W2405247265 cites W2359571009 @default.
• W2405247265 cites W2395092417 @default.
• W2405247265 cites W2395171570 @default.
• W2405247265 cites W2405276556 @default.
• W2405247265 cites W2412171462 @default.
• W2405247265 cites W2416667748 @default.
• W2405247265 cites W2418556453 @default.
• W2405247265 cites W2469560018 @default.
• W2405247265 cites W2470961232 @default.
• W2405247265 cites W298687656 @default.
• W2405247265 cites W4197273 @default.
• W2405247265 doi "https://doi.org/10.1182/blood.v71.5.1461.1461" @default.
• W2405247265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3129049" @default.
• W2405247265 hasPublicationYear "1988" @default.
• W2405247265 type Work @default.
• W2405247265 sameAs 2405247265 @default.
• W2405247265 citedByCount "24" @default.
• W2405247265 countsByYear W24052472652013 @default.
• W2405247265 crossrefType "journal-article" @default.
• W2405247265 hasAuthorship W2405247265A5037616829 @default.
• W2405247265 hasAuthorship W2405247265A5041495085 @default.
• W2405247265 hasAuthorship W2405247265A5058287032 @default.
• W2405247265 hasAuthorship W2405247265A5061926072 @default.
• W2405247265 hasAuthorship W2405247265A5063892070 @default.
• W2405247265 hasBestOaLocation W24052472651 @default.
• W2405247265 hasConcept C153911025 @default.
• W2405247265 hasConcept C184235292 @default.
• W2405247265 hasConcept C195794163 @default.
• W2405247265 hasConcept C203014093 @default.
• W2405247265 hasConcept C2777938653 @default.
• W2405247265 hasConcept C2778461978 @default.
• W2405247265 hasConcept C62478195 @default.
• W2405247265 hasConcept C86803240 @default.
• W2405247265 hasConcept C95444343 @default.
• W2405247265 hasConcept C97029542 @default.
• W2405247265 hasConceptScore W2405247265C153911025 @default.
• W2405247265 hasConceptScore W2405247265C184235292 @default.
• W2405247265 hasConceptScore W2405247265C195794163 @default.
• W2405247265 hasConceptScore W2405247265C203014093 @default.

• next