Matches in SemOpenAlex for { <https://semopenalex.org/work/W2405329564> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2405329564 endingPage "4" @default.
- W2405329564 startingPage "127" @default.
- W2405329564 abstract "We have found that our MDCK-derived cell line (BV-5F1) is non-tumorigenic in tests conducted in accordance with FDA guidelines, and thus may be suitable for producing live, attenuated or inactivated vaccine. The cell line has been extensively tested for the presence of contaminating microorganisms. No infectious agents of viral or other microbial origin were present. Using the BV-5F1 cell line, we have now designed a process for the large-scale production of influenza virus for the manufacture of a vaccine. The production system involves expansion of cells anchored on a microcarrier using stirred fermenters, followed by virus infection. Viral particles are purified in a way similar to the licensed egg-derived vaccine Fluviral SF and mainly involves ultracentrifugation, ultrafiltration and formaldehyde inactivation. The final product is a split inactivated vaccine. A randomized, double-blind clinical study was made in healthy adults using the new split influenza vaccine derived from viruses grown in cell culture (bivalent formulation). The results of this Phase I study have demonstrated that the split influenza vaccine derived from cell culture is highly immunogenic and safe in adults." @default.
- W2405329564 created "2016-06-24" @default.
- W2405329564 creator A5019922432 @default.
- W2405329564 creator A5044266051 @default.
- W2405329564 creator A5087598580 @default.
- W2405329564 creator A5091874206 @default.
- W2405329564 date "1999-01-01" @default.
- W2405329564 modified "2023-10-01" @default.
- W2405329564 title "A Phase I, randomized controlled clinical trial to study the reactogenicity and immunogenicity of a new split influenza vaccine derived from a non-tumorigenic cell line." @default.
- W2405329564 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10494965" @default.
- W2405329564 hasPublicationYear "1999" @default.
- W2405329564 type Work @default.
- W2405329564 sameAs 2405329564 @default.
- W2405329564 citedByCount "6" @default.
- W2405329564 countsByYear W24053295642015 @default.
- W2405329564 countsByYear W24053295642018 @default.
- W2405329564 countsByYear W24053295642022 @default.
- W2405329564 countsByYear W24053295642023 @default.
- W2405329564 crossrefType "journal-article" @default.
- W2405329564 hasAuthorship W2405329564A5019922432 @default.
- W2405329564 hasAuthorship W2405329564A5044266051 @default.
- W2405329564 hasAuthorship W2405329564A5087598580 @default.
- W2405329564 hasAuthorship W2405329564A5091874206 @default.
- W2405329564 hasConcept C133239900 @default.
- W2405329564 hasConcept C159047783 @default.
- W2405329564 hasConcept C159654299 @default.
- W2405329564 hasConcept C176999471 @default.
- W2405329564 hasConcept C203014093 @default.
- W2405329564 hasConcept C2522874641 @default.
- W2405329564 hasConcept C2777704310 @default.
- W2405329564 hasConcept C2780689484 @default.
- W2405329564 hasConcept C2780868878 @default.
- W2405329564 hasConcept C54355233 @default.
- W2405329564 hasConcept C71924100 @default.
- W2405329564 hasConcept C81885089 @default.
- W2405329564 hasConcept C86803240 @default.
- W2405329564 hasConcept C89423630 @default.
- W2405329564 hasConceptScore W2405329564C133239900 @default.
- W2405329564 hasConceptScore W2405329564C159047783 @default.
- W2405329564 hasConceptScore W2405329564C159654299 @default.
- W2405329564 hasConceptScore W2405329564C176999471 @default.
- W2405329564 hasConceptScore W2405329564C203014093 @default.
- W2405329564 hasConceptScore W2405329564C2522874641 @default.
- W2405329564 hasConceptScore W2405329564C2777704310 @default.
- W2405329564 hasConceptScore W2405329564C2780689484 @default.
- W2405329564 hasConceptScore W2405329564C2780868878 @default.
- W2405329564 hasConceptScore W2405329564C54355233 @default.
- W2405329564 hasConceptScore W2405329564C71924100 @default.
- W2405329564 hasConceptScore W2405329564C81885089 @default.
- W2405329564 hasConceptScore W2405329564C86803240 @default.
- W2405329564 hasConceptScore W2405329564C89423630 @default.
- W2405329564 hasLocation W24053295641 @default.
- W2405329564 hasOpenAccess W2405329564 @default.
- W2405329564 hasPrimaryLocation W24053295641 @default.
- W2405329564 hasRelatedWork W2027318795 @default.
- W2405329564 hasRelatedWork W2053375436 @default.
- W2405329564 hasRelatedWork W2066771567 @default.
- W2405329564 hasRelatedWork W2069443938 @default.
- W2405329564 hasRelatedWork W2125247276 @default.
- W2405329564 hasRelatedWork W2152163546 @default.
- W2405329564 hasRelatedWork W2154423341 @default.
- W2405329564 hasRelatedWork W2405329564 @default.
- W2405329564 hasRelatedWork W2412000132 @default.
- W2405329564 hasRelatedWork W576280622 @default.
- W2405329564 hasVolume "98" @default.
- W2405329564 isParatext "false" @default.
- W2405329564 isRetracted "false" @default.
- W2405329564 magId "2405329564" @default.
- W2405329564 workType "article" @default.