Matches in SemOpenAlex for { <https://semopenalex.org/work/W2405333085> ?p ?o ?g. }
- W2405333085 endingPage "1034" @default.
- W2405333085 startingPage "1029" @default.
- W2405333085 abstract "The definitive diagnosis of spotted fever group (SFG) rickettsioses in humans is challenging due to the retrospective nature and cross reactivity of the serological methods and the absence of reliable and consistent samples for molecular diagnostics. Existing data indicate the transient character of bacteremia in experimentally infected animals. The ability of arthropod vectors to acquire rickettsial infection from the laboratory animals in the absence of systemic infection and known tropism of rickettsial agents to endothelial cells of peripheral blood vessels underline the importance of local infection and consequently the diagnostic potential of skin samples. In order to evaluate the diagnostic sensitivity of rickettsial DNA detection in blood and skin samples, we compared results of PCR testing in parallel samples collected from model laboratory animals infected with Rickettsia rickettsii, Rickettsia parkeri and Rickettsia slovaca-like agent at different time points after infection. Skin samples were collected from ears - away from the site of tick placement and without eschars. Overall, testing of skin samples resulted in a higher proportion of positive results than testing of blood samples. Presented data from model animals demonstrates that testing of skin samples from sites of rickettsial proliferation can provide definitive molecular diagnosis of up to 60-70% of tick-borne SFG rickettsial infections during the acute stage of illness. Detection of pathogen DNA in cutaneous samples is a valuable alternative to blood-PCR at least in model animals." @default.
- W2405333085 created "2016-06-24" @default.
- W2405333085 creator A5025302854 @default.
- W2405333085 creator A5030834165 @default.
- W2405333085 creator A5051066586 @default.
- W2405333085 date "2016-07-01" @default.
- W2405333085 modified "2023-10-13" @default.
- W2405333085 title "Comparative value of blood and skin samples for diagnosis of spotted fever group rickettsial infection in model animals" @default.
- W2405333085 cites W136634459 @default.
- W2405333085 cites W1497254863 @default.
- W2405333085 cites W1871250967 @default.
- W2405333085 cites W1981798616 @default.
- W2405333085 cites W1999943856 @default.
- W2405333085 cites W200392105 @default.
- W2405333085 cites W2015008120 @default.
- W2405333085 cites W2017258230 @default.
- W2405333085 cites W2018987750 @default.
- W2405333085 cites W2033295615 @default.
- W2405333085 cites W2038256925 @default.
- W2405333085 cites W2067526788 @default.
- W2405333085 cites W2069898561 @default.
- W2405333085 cites W2093563379 @default.
- W2405333085 cites W2102632394 @default.
- W2405333085 cites W2106939971 @default.
- W2405333085 cites W2119399347 @default.
- W2405333085 cites W2124174722 @default.
- W2405333085 cites W2128010464 @default.
- W2405333085 cites W2146246858 @default.
- W2405333085 cites W2149835544 @default.
- W2405333085 cites W2165485734 @default.
- W2405333085 cites W2170122395 @default.
- W2405333085 cites W2198831883 @default.
- W2405333085 cites W2284216162 @default.
- W2405333085 cites W2289954387 @default.
- W2405333085 cites W2313650661 @default.
- W2405333085 cites W2418864711 @default.
- W2405333085 cites W2422478655 @default.
- W2405333085 cites W2422700241 @default.
- W2405333085 doi "https://doi.org/10.1016/j.ttbdis.2016.05.011" @default.
- W2405333085 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5661872" @default.
- W2405333085 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27282078" @default.
- W2405333085 hasPublicationYear "2016" @default.
- W2405333085 type Work @default.
- W2405333085 sameAs 2405333085 @default.
- W2405333085 citedByCount "21" @default.
- W2405333085 countsByYear W24053330852016 @default.
- W2405333085 countsByYear W24053330852017 @default.
- W2405333085 countsByYear W24053330852018 @default.
- W2405333085 countsByYear W24053330852019 @default.
- W2405333085 countsByYear W24053330852020 @default.
- W2405333085 countsByYear W24053330852021 @default.
- W2405333085 countsByYear W24053330852022 @default.
- W2405333085 countsByYear W24053330852023 @default.
- W2405333085 crossrefType "journal-article" @default.
- W2405333085 hasAuthorship W2405333085A5025302854 @default.
- W2405333085 hasAuthorship W2405333085A5030834165 @default.
- W2405333085 hasAuthorship W2405333085A5051066586 @default.
- W2405333085 hasBestOaLocation W24053330851 @default.
- W2405333085 hasConcept C104317684 @default.
- W2405333085 hasConcept C159047783 @default.
- W2405333085 hasConcept C159654299 @default.
- W2405333085 hasConcept C203014093 @default.
- W2405333085 hasConcept C2522874641 @default.
- W2405333085 hasConcept C2776005033 @default.
- W2405333085 hasConcept C2776460866 @default.
- W2405333085 hasConcept C2778424734 @default.
- W2405333085 hasConcept C2779620486 @default.
- W2405333085 hasConcept C2780414542 @default.
- W2405333085 hasConcept C2780868683 @default.
- W2405333085 hasConcept C45189115 @default.
- W2405333085 hasConcept C49105822 @default.
- W2405333085 hasConcept C533803919 @default.
- W2405333085 hasConcept C55493867 @default.
- W2405333085 hasConcept C86803240 @default.
- W2405333085 hasConceptScore W2405333085C104317684 @default.
- W2405333085 hasConceptScore W2405333085C159047783 @default.
- W2405333085 hasConceptScore W2405333085C159654299 @default.
- W2405333085 hasConceptScore W2405333085C203014093 @default.
- W2405333085 hasConceptScore W2405333085C2522874641 @default.
- W2405333085 hasConceptScore W2405333085C2776005033 @default.
- W2405333085 hasConceptScore W2405333085C2776460866 @default.
- W2405333085 hasConceptScore W2405333085C2778424734 @default.
- W2405333085 hasConceptScore W2405333085C2779620486 @default.
- W2405333085 hasConceptScore W2405333085C2780414542 @default.
- W2405333085 hasConceptScore W2405333085C2780868683 @default.
- W2405333085 hasConceptScore W2405333085C45189115 @default.
- W2405333085 hasConceptScore W2405333085C49105822 @default.
- W2405333085 hasConceptScore W2405333085C533803919 @default.
- W2405333085 hasConceptScore W2405333085C55493867 @default.
- W2405333085 hasConceptScore W2405333085C86803240 @default.
- W2405333085 hasFunder F4320306084 @default.
- W2405333085 hasFunder F4320332162 @default.
- W2405333085 hasFunder F4320332382 @default.
- W2405333085 hasIssue "5" @default.
- W2405333085 hasLocation W24053330851 @default.
- W2405333085 hasLocation W24053330852 @default.
- W2405333085 hasLocation W24053330853 @default.
- W2405333085 hasLocation W24053330854 @default.