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• W2405397923 abstract "Abstract Regulatory networks play a central role in the modulation of gene expression, the control of cellular differentiation, and the emergence of complex phenotypes. Regulatory networks could constrain or facilitate evolutionary adaptation in gene expression levels. Here, we model the adaptation of regulatory networks and gene expression levels to a shift in the environment that alters the optimal expression level of a single gene. Our analyses show signatures of natural selection on regulatory networks that both constrain and facilitate rapid evolution of gene expression level towards new optima. The analyses are interpreted from the standpoint of neutral expectations and illustrate the challenge to making inferences about network adaptation. Furthermore, we examine the consequence of variable stabilizing selection across genes on the strength and direction of interactions in regulatory networks and in their subsequent adaptation. We observe that directional selection on a highly constrained gene previously under strong stabilizing selection was more efficient when the gene was embedded within a network of partners under relaxed stabilizing selection pressure. The observation leads to the expectation that evolutionarily resilient regulatory networks will contain optimal ratios of genes whose expression is under weak and strong stabilizing selection. Altogether, our results suggest that the variable strengths of stabilizing selection across genes within regulatory networks might itself contribute to the long‐term adaptation of complex phenotypes." @default.
• W2405397923 created "2016-06-24" @default.
• W2405397923 creator A5020961284 @default.
• W2405397923 creator A5062865486 @default.
• W2405397923 creator A5091754598 @default.
• W2405397923 date "2016-06-20" @default.
• W2405397923 modified "2023-10-03" @default.
• W2405397923 title "Genes under weaker stabilizing selection increase network evolvability and rapid regulatory adaptation to an environmental shift" @default.
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• W2405397923 doi "https://doi.org/10.1111/jeb.12897" @default.
• W2405397923 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27213992" @default.
• W2405397923 hasPublicationYear "2016" @default.
• W2405397923 type Work @default.
• W2405397923 sameAs 2405397923 @default.

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