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- W2405457718 abstract "Fast and precise heating by microwave irradiation during solid-phase peptide synthesis (SPPS) can reduce reaction times as well as provide better purities and greater yields for the synthesis of difficult peptides. Microwave- assisted SPPS has proven to be a useful and reliable tool for the synthesis of peptides as well as small proteins. It is particularly well suited for sequences with a high propensity to form β-sheet-type structures and for sterically difficult couplings. In this protocol, conditions and detailed procedures are described for performing microwave-assisted SPPS using the Syro Wave™. Here we describe the synthesis of two difficult peptide sequences: the first is derived from the C-terminus of the MuLV CTL epitope, the second is a de novo designed peptide with a C-terminal alkyne." @default.
- W2405457718 created "2016-06-24" @default.
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- W2405457718 date "2013-01-01" @default.
- W2405457718 modified "2023-09-26" @default.
- W2405457718 title "Microwave-Assisted Solid-Phase Peptide Synthesis Using the Biotage Syro Wave™" @default.
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- W2405457718 doi "https://doi.org/10.1007/978-1-62703-544-6_16" @default.
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