Matches in SemOpenAlex for { <https://semopenalex.org/work/W2405613983> ?p ?o ?g. }
Showing items 1 to 60 of
60
with 100 items per page.
- W2405613983 abstract "Vitamin A alcohol (retinol) completely Inhibited the mutagenicity of the carcinogen 2-fluorenamine (2-FA) in Salmonella typhimurium TA98 when the mutagen was activated by liver microsomes from CFN rats. The mutagenicity of 2-FA activated by 9,000×g rat liver supernatant S9 was inhibited by retinol to a lesser degree. The decline in the number of his+ revertants was not an artifact due to bacterial killing, inasmuch as retinol was not toxic to the bacteria at levels that totally inhibited mutagenesis by 2-FA. Mutagenesis induced by adrlamycin, an antibiotic that does not require metabolic activation for mutagenic potential, was unaffected by vitamin A. These results indicate that retlnoids inhibit the metabolic activation of some chemical carcinogens to forms that can interact with DNA. Our findings are consistent with the hypothesis that retinoids may exert anticancer activity by inhibiting carcinogen activation, thereby inhibiting tumor induction, in addition to the more widely accepted role of retinoids in modulating the proliferation of eplthelially derived neoplasms." @default.
- W2405613983 created "2016-06-24" @default.
- W2405613983 date "1979-10-01" @default.
- W2405613983 modified "2023-09-26" @default.
- W2405613983 title "Inhibition of 2-Fluorenamine-Induced Mutagenesis in <italic>Salmonella typhimurium</italic> by Vitamin A<xref ref-type=fn rid=FN2>2</xref>" @default.
- W2405613983 doi "https://doi.org/10.1093/jnci/63.4.1093" @default.
- W2405613983 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/384006" @default.
- W2405613983 hasPublicationYear "1979" @default.
- W2405613983 type Work @default.
- W2405613983 sameAs 2405613983 @default.
- W2405613983 citedByCount "8" @default.
- W2405613983 crossrefType "journal-article" @default.
- W2405613983 hasConcept C104317684 @default.
- W2405613983 hasConcept C114246631 @default.
- W2405613983 hasConcept C153911025 @default.
- W2405613983 hasConcept C16318435 @default.
- W2405613983 hasConcept C185592680 @default.
- W2405613983 hasConcept C2776639595 @default.
- W2405613983 hasConcept C2776940978 @default.
- W2405613983 hasConcept C2779573558 @default.
- W2405613983 hasConcept C2781065037 @default.
- W2405613983 hasConcept C501734568 @default.
- W2405613983 hasConcept C523546767 @default.
- W2405613983 hasConcept C54355233 @default.
- W2405613983 hasConcept C55493867 @default.
- W2405613983 hasConcept C86803240 @default.
- W2405613983 hasConcept C98274493 @default.
- W2405613983 hasConceptScore W2405613983C104317684 @default.
- W2405613983 hasConceptScore W2405613983C114246631 @default.
- W2405613983 hasConceptScore W2405613983C153911025 @default.
- W2405613983 hasConceptScore W2405613983C16318435 @default.
- W2405613983 hasConceptScore W2405613983C185592680 @default.
- W2405613983 hasConceptScore W2405613983C2776639595 @default.
- W2405613983 hasConceptScore W2405613983C2776940978 @default.
- W2405613983 hasConceptScore W2405613983C2779573558 @default.
- W2405613983 hasConceptScore W2405613983C2781065037 @default.
- W2405613983 hasConceptScore W2405613983C501734568 @default.
- W2405613983 hasConceptScore W2405613983C523546767 @default.
- W2405613983 hasConceptScore W2405613983C54355233 @default.
- W2405613983 hasConceptScore W2405613983C55493867 @default.
- W2405613983 hasConceptScore W2405613983C86803240 @default.
- W2405613983 hasConceptScore W2405613983C98274493 @default.
- W2405613983 hasLocation W24056139831 @default.
- W2405613983 hasLocation W24056139832 @default.
- W2405613983 hasOpenAccess W2405613983 @default.
- W2405613983 hasPrimaryLocation W24056139831 @default.
- W2405613983 hasRelatedWork W1562378241 @default.
- W2405613983 hasRelatedWork W1571176283 @default.
- W2405613983 hasRelatedWork W1976921180 @default.
- W2405613983 hasRelatedWork W1980343372 @default.
- W2405613983 hasRelatedWork W1998936261 @default.
- W2405613983 hasRelatedWork W2047639760 @default.
- W2405613983 hasRelatedWork W2067325722 @default.
- W2405613983 hasRelatedWork W2132044867 @default.
- W2405613983 hasRelatedWork W2405613983 @default.
- W2405613983 hasRelatedWork W3129740094 @default.
- W2405613983 isParatext "false" @default.
- W2405613983 isRetracted "false" @default.
- W2405613983 magId "2405613983" @default.
- W2405613983 workType "article" @default.