Matches in SemOpenAlex for { <https://semopenalex.org/work/W2405665559> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2405665559 abstract "The advent of combined antiretroviral therapy effectively undermined the evolution of HIV disease. Nevertheless, clinical observations indicated a clear association between therapy and the impairment of bone mineral density.We selected some antiretroviral compounds used in clinical practice, to study their impact on bone health and their possible implication in the onset of bone disease.Scalar concentrations of several antiretroviral drugs (used in single and in combination) were tested on an osteoblast-like cell line, HOBIT cells, to analyse cell survival and gene expression of selected bone markers.None of the tested concentrations of Tenofovir, Emtricitabine, Nevirapine, Maraviroc or Raltegravir induced any significant apoptosis activation at our experimental conditions. Only some protease inhibitors and Efavirenz, at high concentration, determined a significant activation of programmed cell death. In parallel experiments, protease inhibitors used in combination with Tenofovir and Emtricitabine, increased apoptosis. Furthermore, we performed a study of mRNA expression of specific genes involved in osteoblast biology and in bone synthesis and observed that some protease inhibitors induced a selective decrease of some osteogenic markers.All the protease inhibitors included in this study trigger apoptosis at the highest concentration analysed, suggesting great caution in HIV-patients co-infected with HBV or HCV, where elevated plasma concentrations of drugs could be reached as a consequence of liver failure. Lastly, an increased apoptosis rate and an impairment of osteogenic markers were recorded only in the presence of Nelfinavir, suggesting a role of protease inhibitors in the alteration of osteoblast biology." @default.
- W2405665559 created "2016-06-24" @default.
- W2405665559 creator A5011650354 @default.
- W2405665559 creator A5013200935 @default.
- W2405665559 creator A5024975408 @default.
- W2405665559 creator A5039414607 @default.
- W2405665559 creator A5049985255 @default.
- W2405665559 creator A5050738151 @default.
- W2405665559 creator A5079329316 @default.
- W2405665559 creator A5079709625 @default.
- W2405665559 date "2016-11-02" @default.
- W2405665559 modified "2023-10-05" @default.
- W2405665559 title "Effects of Antiretroviral Molecules on Survival and Gene Expression of An Osteoblast-like Cell Line" @default.
- W2405665559 doi "https://doi.org/10.2174/1570162x14666160518121915" @default.
- W2405665559 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27189027" @default.
- W2405665559 hasPublicationYear "2016" @default.
- W2405665559 type Work @default.
- W2405665559 sameAs 2405665559 @default.
- W2405665559 citedByCount "1" @default.
- W2405665559 countsByYear W24056655592017 @default.
- W2405665559 crossrefType "journal-article" @default.
- W2405665559 hasAuthorship W2405665559A5011650354 @default.
- W2405665559 hasAuthorship W2405665559A5013200935 @default.
- W2405665559 hasAuthorship W2405665559A5024975408 @default.
- W2405665559 hasAuthorship W2405665559A5039414607 @default.
- W2405665559 hasAuthorship W2405665559A5049985255 @default.
- W2405665559 hasAuthorship W2405665559A5050738151 @default.
- W2405665559 hasAuthorship W2405665559A5079329316 @default.
- W2405665559 hasAuthorship W2405665559A5079709625 @default.
- W2405665559 hasConcept C142462285 @default.
- W2405665559 hasConcept C181199279 @default.
- W2405665559 hasConcept C185592680 @default.
- W2405665559 hasConcept C190283241 @default.
- W2405665559 hasConcept C202751555 @default.
- W2405665559 hasConcept C203014093 @default.
- W2405665559 hasConcept C2522874641 @default.
- W2405665559 hasConcept C2776714187 @default.
- W2405665559 hasConcept C2777182164 @default.
- W2405665559 hasConcept C2777869810 @default.
- W2405665559 hasConcept C2778260815 @default.
- W2405665559 hasConcept C2779130552 @default.
- W2405665559 hasConcept C2779778239 @default.
- W2405665559 hasConcept C2780593183 @default.
- W2405665559 hasConcept C2781160516 @default.
- W2405665559 hasConcept C2781432083 @default.
- W2405665559 hasConcept C2993143319 @default.
- W2405665559 hasConcept C3013748606 @default.
- W2405665559 hasConcept C502942594 @default.
- W2405665559 hasConcept C55493867 @default.
- W2405665559 hasConcept C86803240 @default.
- W2405665559 hasConcept C98274493 @default.
- W2405665559 hasConceptScore W2405665559C142462285 @default.
- W2405665559 hasConceptScore W2405665559C181199279 @default.
- W2405665559 hasConceptScore W2405665559C185592680 @default.
- W2405665559 hasConceptScore W2405665559C190283241 @default.
- W2405665559 hasConceptScore W2405665559C202751555 @default.
- W2405665559 hasConceptScore W2405665559C203014093 @default.
- W2405665559 hasConceptScore W2405665559C2522874641 @default.
- W2405665559 hasConceptScore W2405665559C2776714187 @default.
- W2405665559 hasConceptScore W2405665559C2777182164 @default.
- W2405665559 hasConceptScore W2405665559C2777869810 @default.
- W2405665559 hasConceptScore W2405665559C2778260815 @default.
- W2405665559 hasConceptScore W2405665559C2779130552 @default.
- W2405665559 hasConceptScore W2405665559C2779778239 @default.
- W2405665559 hasConceptScore W2405665559C2780593183 @default.
- W2405665559 hasConceptScore W2405665559C2781160516 @default.
- W2405665559 hasConceptScore W2405665559C2781432083 @default.
- W2405665559 hasConceptScore W2405665559C2993143319 @default.
- W2405665559 hasConceptScore W2405665559C3013748606 @default.
- W2405665559 hasConceptScore W2405665559C502942594 @default.
- W2405665559 hasConceptScore W2405665559C55493867 @default.
- W2405665559 hasConceptScore W2405665559C86803240 @default.
- W2405665559 hasConceptScore W2405665559C98274493 @default.
- W2405665559 hasLocation W24056655591 @default.
- W2405665559 hasLocation W24056655592 @default.
- W2405665559 hasOpenAccess W2405665559 @default.
- W2405665559 hasPrimaryLocation W24056655591 @default.
- W2405665559 hasRelatedWork W2000813879 @default.
- W2405665559 hasRelatedWork W2028787913 @default.
- W2405665559 hasRelatedWork W2071732113 @default.
- W2405665559 hasRelatedWork W2087525467 @default.
- W2405665559 hasRelatedWork W2096675880 @default.
- W2405665559 hasRelatedWork W2113389936 @default.
- W2405665559 hasRelatedWork W2405665559 @default.
- W2405665559 hasRelatedWork W2565202933 @default.
- W2405665559 hasRelatedWork W2566908671 @default.
- W2405665559 hasRelatedWork W2980864032 @default.
- W2405665559 isParatext "false" @default.
- W2405665559 isRetracted "false" @default.
- W2405665559 magId "2405665559" @default.
- W2405665559 workType "article" @default.