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- W2405812378 abstract "Purpose: Extraocular muscle (EOM) consists of two layers, the global and the orbital layer, which are readily distinguished by their histopathology. This study was conducted to investigate the changes of myosin heavy chain (MHC) and MHC isoforms of the global and the orbital layers of EOM after tenotomy. Methods: Twenty four New Zealand white rabbits were used. The rectns muscles were harvested on day 3, week 1, week 2, week 3, week 4, and week 8 after EOM tenotomy. The change of MHC amount was measured using an electrophoresis. The changes of MHC isoforms were also measured quantitatively using western blot immunostaining, Results: The amount of total MHC, fast MHC isofonn, and slow MHC isofonn decreased maximally at 1-week after EOM tenotomy and recovered at 4-week and 8-week after tenotomy. There was no significant change in the amount of the neonatal and developmental MHC isofonn. Conclusions: Fast and slow MHC isoform changed mainly due to the changes in the global layer rather than in the orbital layer after EOM tenotomy." @default.
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- W2405812378 date "2003-01-01" @default.
- W2405812378 modified "2023-09-24" @default.
- W2405812378 title "The Changes of Myosin Heavy Chain Isoforms after Tenotomy on Extraocular Muscle Layers of Rabbits" @default.
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