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- W2405842210 abstract "The effect of intracerebroventricularly (i.c.v.) administered Asn-Ala-Gly-Ala (NAGA), a partial sequence of beta-lipotropin, was investigated using the tail-pressure, hot-plate and phenylbenzoquinone (PBQ)-induced writhing tests in mice. I.c.v. administration of NAGA produced a dose-dependent inhibition of responses as measured by the three different assays. The ED50 of NAGA on the tail-pressure test did not differ from that obtained on the hot-plate test. NAGA showed a prominent reduction in activity on the PBQ writhing as compared with the hot-plate and tail-pressure tests. A low dose of naloxone (0.1-1.0 mg/kg, s.c.) resulted in a dose-dependent antagonism of the effect of NAGA in all assays. These data suggest that the antinociceptive effect induced by NAGA may involve the endogenous opioid system in mice." @default.
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- W2405842210 date "1985-10-01" @default.
- W2405842210 modified "2023-09-23" @default.
- W2405842210 title "Antinociceptive properties of a new tetrapeptide, Asn-Ala-Gly-Ala, in mice." @default.
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