Matches in SemOpenAlex for { <https://semopenalex.org/work/W2405874976> ?p ?o ?g. }
- W2405874976 abstract "Abstract Degenerative aortic stenosis (AS) is the most common worldwide cause of valve replacement. The aortic valve is a thin, complex, layered connective tissue with compartmentalized extracellular matrix (ECM) produced by specialized cell types, which directs blood flow in one direction through the heart. There is evidence suggesting remodeling of such ECM during aortic stenosis development. Thus, a better characterization of the role of ECM proteins in this disease would increase our understanding of the underlying molecular mechanisms. Aortic valve samples were collected from 18 patients which underwent aortic valve replacement (50% males, mean age of 74 years) and 18 normal control valves were obtained from necropsies (40% males, mean age of 69 years). The proteome of the samples was analyzed by 2D-LC MS/MS iTRAQ methodology. The results showed an altered expression of 13 ECM proteins of which 3 (biglycan, periostin, prolargin) were validated by Western blotting and/or SRM analyses. These findings are substantiated by our previous results demonstrating differential ECM protein expression. The present study has demonstrated a differential ECM protein pattern in individuals with AS, therefore supporting previous evidence of a dynamic ECM remodeling in human aortic valves during AS development." @default.
- W2405874976 created "2016-06-24" @default.
- W2405874976 creator A5014237010 @default.
- W2405874976 creator A5014583829 @default.
- W2405874976 creator A5035007074 @default.
- W2405874976 creator A5040324785 @default.
- W2405874976 creator A5051369406 @default.
- W2405874976 creator A5052366300 @default.
- W2405874976 creator A5053531262 @default.
- W2405874976 creator A5068931629 @default.
- W2405874976 creator A5073396313 @default.
- W2405874976 creator A5073848424 @default.
- W2405874976 creator A5083828305 @default.
- W2405874976 date "2015-12-01" @default.
- W2405874976 modified "2023-10-16" @default.
- W2405874976 title "iTRAQ proteomic analysis of extracellular matrix remodeling in aortic valve disease" @default.
- W2405874976 cites W1599429544 @default.
- W2405874976 cites W1793555134 @default.
- W2405874976 cites W1910862521 @default.
- W2405874976 cites W1967872610 @default.
- W2405874976 cites W1977991799 @default.
- W2405874976 cites W1984988601 @default.
- W2405874976 cites W1987383242 @default.
- W2405874976 cites W1987664863 @default.
- W2405874976 cites W199420291 @default.
- W2405874976 cites W1996205099 @default.
- W2405874976 cites W2000146219 @default.
- W2405874976 cites W2002468760 @default.
- W2405874976 cites W2003448820 @default.
- W2405874976 cites W2005818888 @default.
- W2405874976 cites W2010501457 @default.
- W2405874976 cites W2010701670 @default.
- W2405874976 cites W2011170808 @default.
- W2405874976 cites W2017743016 @default.
- W2405874976 cites W2019405824 @default.
- W2405874976 cites W2029176068 @default.
- W2405874976 cites W2041125186 @default.
- W2405874976 cites W2048678109 @default.
- W2405874976 cites W2050931186 @default.
- W2405874976 cites W2051093466 @default.
- W2405874976 cites W2054228700 @default.
- W2405874976 cites W2071238583 @default.
- W2405874976 cites W2073764175 @default.
- W2405874976 cites W2078828031 @default.
- W2405874976 cites W2082255168 @default.
- W2405874976 cites W2089363778 @default.
- W2405874976 cites W2093508343 @default.
- W2405874976 cites W2096280138 @default.
- W2405874976 cites W2096499490 @default.
- W2405874976 cites W2097900801 @default.
- W2405874976 cites W2106452931 @default.
- W2405874976 cites W2117423001 @default.
- W2405874976 cites W2117509155 @default.
- W2405874976 cites W2127801411 @default.
- W2405874976 cites W2128635872 @default.
- W2405874976 cites W2133465414 @default.
- W2405874976 cites W2137701250 @default.
- W2405874976 cites W2144578510 @default.
- W2405874976 cites W2150750426 @default.
- W2405874976 cites W2154613259 @default.
- W2405874976 cites W2156622588 @default.
- W2405874976 cites W2161411353 @default.
- W2405874976 cites W2162452658 @default.
- W2405874976 cites W2163408805 @default.
- W2405874976 cites W2167149037 @default.
- W2405874976 cites W2167631115 @default.
- W2405874976 cites W2169947701 @default.
- W2405874976 cites W2171649931 @default.
- W2405874976 cites W4293247451 @default.
- W2405874976 doi "https://doi.org/10.1038/srep17290" @default.
- W2405874976 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4664895" @default.
- W2405874976 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26620461" @default.
- W2405874976 hasPublicationYear "2015" @default.
- W2405874976 type Work @default.
- W2405874976 sameAs 2405874976 @default.
- W2405874976 citedByCount "35" @default.
- W2405874976 countsByYear W24058749762016 @default.
- W2405874976 countsByYear W24058749762017 @default.
- W2405874976 countsByYear W24058749762018 @default.
- W2405874976 countsByYear W24058749762019 @default.
- W2405874976 countsByYear W24058749762020 @default.
- W2405874976 countsByYear W24058749762021 @default.
- W2405874976 countsByYear W24058749762022 @default.
- W2405874976 countsByYear W24058749762023 @default.
- W2405874976 crossrefType "journal-article" @default.
- W2405874976 hasAuthorship W2405874976A5014237010 @default.
- W2405874976 hasAuthorship W2405874976A5014583829 @default.
- W2405874976 hasAuthorship W2405874976A5035007074 @default.
- W2405874976 hasAuthorship W2405874976A5040324785 @default.
- W2405874976 hasAuthorship W2405874976A5051369406 @default.
- W2405874976 hasAuthorship W2405874976A5052366300 @default.
- W2405874976 hasAuthorship W2405874976A5053531262 @default.
- W2405874976 hasAuthorship W2405874976A5068931629 @default.
- W2405874976 hasAuthorship W2405874976A5073396313 @default.
- W2405874976 hasAuthorship W2405874976A5073848424 @default.
- W2405874976 hasAuthorship W2405874976A5083828305 @default.
- W2405874976 hasBestOaLocation W24058749761 @default.
- W2405874976 hasConcept C104397665 @default.
- W2405874976 hasConcept C126322002 @default.
- W2405874976 hasConcept C142724271 @default.