Matches in SemOpenAlex for { <https://semopenalex.org/work/W2405895425> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2405895425 endingPage "5" @default.
- W2405895425 startingPage "201" @default.
- W2405895425 abstract "Adherence of various leukocytes, including monocyte, to vascular endothelial cells may play an important role in the development of atherosclerosis. In vivo, the hemodynamic shear forces have a critical effect on the surface expression of adhesion proteins. In order to elucidate the effect of flow shear stress on the expression of adhesion molecules of endothelial cells, we investigated the effect of flow shear stress (2.23-6.08 dyne/cm2) on the expression of adhesive molecules, intercellular adhesion molecule(ICAM-1), vascular cell adhesion molecule (VCAM-1), and E-selectin on cultured human umbilical vein endothelial cells(HUVECs). The expression of adhesion molecules on the surface of HUVECs induced by shear stress was analyzed using flow cytometry. The results showed that compared with stationary control, the surface expression of ICAM-1 was significantly increased (P < 0.05) on HUVECs after exposure to different shear stress (2.23, 4.20, 6.08 dyne/cm2), and it was found to be in close relationship with the shearing time (r = 0.992, 0.997, 0.997; P < 0.05). After exposure to shear(2.23 dyne/cm2), VCAM-1 expression was significant increased(P < 0.05), and it was positively correlated with the shearing time(r = 0.930; P < 0.05), while VCAM-1 expression dropped down to basal level(P < 0.05) after it was sheared at 4.20 or 6.08 dyne/cm2, and the magnitude of the reduction of VCAM-1 expression was negatively correlated with the shearing time (r = -0.975, -0.989; P < 0.05). E-selectin expression was less sensitive to shear stress, especially at the lower magnitudes of shear. These results indicate that the increase of ICAM-1 and VCAM-1 expression in endothelial cells induced by low shear stress may play a prominent role in the development of both inflammation and atherosclerosis." @default.
- W2405895425 created "2016-06-24" @default.
- W2405895425 creator A5012048085 @default.
- W2405895425 creator A5016042943 @default.
- W2405895425 creator A5036927646 @default.
- W2405895425 creator A5050892138 @default.
- W2405895425 creator A5074367720 @default.
- W2405895425 creator A5088587483 @default.
- W2405895425 date "2001-06-01" @default.
- W2405895425 modified "2023-09-26" @default.
- W2405895425 title "[Effect of flow shear stress on the expression of adhesion molecules of endothelial cells]." @default.
- W2405895425 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11450534" @default.
- W2405895425 hasPublicationYear "2001" @default.
- W2405895425 type Work @default.
- W2405895425 sameAs 2405895425 @default.
- W2405895425 citedByCount "0" @default.
- W2405895425 crossrefType "journal-article" @default.
- W2405895425 hasAuthorship W2405895425A5012048085 @default.
- W2405895425 hasAuthorship W2405895425A5016042943 @default.
- W2405895425 hasAuthorship W2405895425A5036927646 @default.
- W2405895425 hasAuthorship W2405895425A5050892138 @default.
- W2405895425 hasAuthorship W2405895425A5074367720 @default.
- W2405895425 hasAuthorship W2405895425A5088587483 @default.
- W2405895425 hasConcept C123012128 @default.
- W2405895425 hasConcept C12554922 @default.
- W2405895425 hasConcept C152279782 @default.
- W2405895425 hasConcept C153911025 @default.
- W2405895425 hasConcept C159985019 @default.
- W2405895425 hasConcept C16224149 @default.
- W2405895425 hasConcept C178790620 @default.
- W2405895425 hasConcept C185592680 @default.
- W2405895425 hasConcept C185946421 @default.
- W2405895425 hasConcept C192562407 @default.
- W2405895425 hasConcept C202751555 @default.
- W2405895425 hasConcept C21141959 @default.
- W2405895425 hasConcept C2776985958 @default.
- W2405895425 hasConcept C2777411675 @default.
- W2405895425 hasConcept C2909375385 @default.
- W2405895425 hasConcept C553184892 @default.
- W2405895425 hasConcept C55493867 @default.
- W2405895425 hasConcept C84416704 @default.
- W2405895425 hasConcept C85789140 @default.
- W2405895425 hasConcept C86803240 @default.
- W2405895425 hasConcept C95444343 @default.
- W2405895425 hasConceptScore W2405895425C123012128 @default.
- W2405895425 hasConceptScore W2405895425C12554922 @default.
- W2405895425 hasConceptScore W2405895425C152279782 @default.
- W2405895425 hasConceptScore W2405895425C153911025 @default.
- W2405895425 hasConceptScore W2405895425C159985019 @default.
- W2405895425 hasConceptScore W2405895425C16224149 @default.
- W2405895425 hasConceptScore W2405895425C178790620 @default.
- W2405895425 hasConceptScore W2405895425C185592680 @default.
- W2405895425 hasConceptScore W2405895425C185946421 @default.
- W2405895425 hasConceptScore W2405895425C192562407 @default.
- W2405895425 hasConceptScore W2405895425C202751555 @default.
- W2405895425 hasConceptScore W2405895425C21141959 @default.
- W2405895425 hasConceptScore W2405895425C2776985958 @default.
- W2405895425 hasConceptScore W2405895425C2777411675 @default.
- W2405895425 hasConceptScore W2405895425C2909375385 @default.
- W2405895425 hasConceptScore W2405895425C553184892 @default.
- W2405895425 hasConceptScore W2405895425C55493867 @default.
- W2405895425 hasConceptScore W2405895425C84416704 @default.
- W2405895425 hasConceptScore W2405895425C85789140 @default.
- W2405895425 hasConceptScore W2405895425C86803240 @default.
- W2405895425 hasConceptScore W2405895425C95444343 @default.
- W2405895425 hasIssue "2" @default.
- W2405895425 hasLocation W24058954251 @default.
- W2405895425 hasOpenAccess W2405895425 @default.
- W2405895425 hasPrimaryLocation W24058954251 @default.
- W2405895425 hasRelatedWork W1971423643 @default.
- W2405895425 hasRelatedWork W1977364241 @default.
- W2405895425 hasRelatedWork W2022231939 @default.
- W2405895425 hasRelatedWork W2045540954 @default.
- W2405895425 hasRelatedWork W2078417286 @default.
- W2405895425 hasRelatedWork W2184711441 @default.
- W2405895425 hasRelatedWork W2369527353 @default.
- W2405895425 hasRelatedWork W2393648991 @default.
- W2405895425 hasRelatedWork W257384994 @default.
- W2405895425 hasRelatedWork W215753852 @default.
- W2405895425 hasVolume "18" @default.
- W2405895425 isParatext "false" @default.
- W2405895425 isRetracted "false" @default.
- W2405895425 magId "2405895425" @default.
- W2405895425 workType "article" @default.