FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2405970994> ?p ?o ?g. }

• W2405970994 abstract "Immunologic targeting of the mediators of sepsis is a new approach to reducing mortality associated with this often-fatal complication. When sepsis is due to infection with a gram-negative pathogen, endotoxin plays a key role in its pathogenesis. Antiendotoxin antibody E5 binds endotoxin from a broad spectrum of clinically relevant gram-negative bacteria and reduces mortality from endotoxemia and bacteremia in animal models. It seems to be safe to administer to patients with suspected gram-negative sepsis; fewer than 2% of patients experienced allergic-type reactions, a frequency similar to that seen with third-generation cephalosporins. When administered in a dose of 2 mg/kg daily for two days, E5 reduces mortality and improves the outcome of multi-organ failure in patients with gram-negative sepsis, especially when administered before the development of refractory shock. Patients with sepsis of other etiology have not been shown to benefit from antiendotoxin immunotherapy. E5 antibody appears to be an effective agent for the adjunctive treatment of gram-negative sepsis. Further evaluation of E5 antibody is warranted in the treatment of patients with neutropenia, burns, and shock." @default.
• W2405970994 created "2016-06-24" @default.
• W2405970994 creator A5008704510 @default.
• W2405970994 creator A5069703991 @default.
• W2405970994 date "1991-12-01" @default.
• W2405970994 modified "2023-10-18" @default.
• W2405970994 title "The Role of Monoclonal Antibodies in the Management of Gram-negative Sepsis" @default.
• W2405970994 cites W1552570230 @default.
• W2405970994 cites W1581935652 @default.
• W2405970994 cites W1726769027 @default.
• W2405970994 cites W1923128572 @default.
• W2405970994 cites W1965323794 @default.
• W2405970994 cites W1980447250 @default.
• W2405970994 cites W1992258769 @default.
• W2405970994 cites W1992644897 @default.
• W2405970994 cites W1994604086 @default.
• W2405970994 cites W2000421482 @default.
• W2405970994 cites W2006727267 @default.
• W2405970994 cites W2024722026 @default.
• W2405970994 cites W2038252730 @default.
• W2405970994 cites W2038998020 @default.
• W2405970994 cites W2039602526 @default.
• W2405970994 cites W2044003032 @default.
• W2405970994 cites W2049332147 @default.
• W2405970994 cites W2058592677 @default.
• W2405970994 cites W2063683669 @default.
• W2405970994 cites W2064107559 @default.
• W2405970994 cites W2065022523 @default.
• W2405970994 cites W2068305588 @default.
• W2405970994 cites W2071670327 @default.
• W2405970994 cites W2072117769 @default.
• W2405970994 cites W2079778072 @default.
• W2405970994 cites W2081441884 @default.
• W2405970994 cites W2083305340 @default.
• W2405970994 cites W2086967708 @default.
• W2405970994 cites W2089179708 @default.
• W2405970994 cites W2093816949 @default.
• W2405970994 cites W2129889238 @default.
• W2405970994 cites W2135164896 @default.
• W2405970994 cites W2137086741 @default.
• W2405970994 cites W2148860016 @default.
• W2405970994 cites W2149549410 @default.
• W2405970994 cites W2302310184 @default.
• W2405970994 cites W2313377382 @default.
• W2405970994 cites W2322176030 @default.
• W2405970994 cites W2328804315 @default.
• W2405970994 cites W2336871225 @default.
• W2405970994 cites W2399829861 @default.
• W2405970994 cites W2616307005 @default.
• W2405970994 cites W4233474789 @default.
• W2405970994 cites W4298273896 @default.
• W2405970994 cites W4301376333 @default.
• W2405970994 doi "https://doi.org/10.1016/s0891-5520(20)30763-7" @default.
• W2405970994 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1783775" @default.
• W2405970994 hasPublicationYear "1991" @default.
• W2405970994 type Work @default.
• W2405970994 sameAs 2405970994 @default.
• W2405970994 citedByCount "3" @default.
• W2405970994 countsByYear W24059709942020 @default.
• W2405970994 crossrefType "journal-article" @default.
• W2405970994 hasAuthorship W2405970994A5008704510 @default.
• W2405970994 hasAuthorship W2405970994A5069703991 @default.
• W2405970994 hasConcept C121332964 @default.
• W2405970994 hasConcept C126322002 @default.
• W2405970994 hasConcept C137627325 @default.
• W2405970994 hasConcept C142424586 @default.
• W2405970994 hasConcept C159654299 @default.
• W2405970994 hasConcept C177713679 @default.
• W2405970994 hasConcept C203014093 @default.
• W2405970994 hasConcept C2776694085 @default.
• W2405970994 hasConcept C2777063308 @default.
• W2405970994 hasConcept C2777628635 @default.
• W2405970994 hasConcept C2777701055 @default.
• W2405970994 hasConcept C2778384902 @default.
• W2405970994 hasConcept C2779443120 @default.
• W2405970994 hasConcept C2781300812 @default.
• W2405970994 hasConcept C501593827 @default.
• W2405970994 hasConcept C542903549 @default.
• W2405970994 hasConcept C71924100 @default.
• W2405970994 hasConcept C86803240 @default.
• W2405970994 hasConcept C87355193 @default.
• W2405970994 hasConcept C8891405 @default.
• W2405970994 hasConcept C89423630 @default.
• W2405970994 hasConceptScore W2405970994C121332964 @default.
• W2405970994 hasConceptScore W2405970994C126322002 @default.
• W2405970994 hasConceptScore W2405970994C137627325 @default.
• W2405970994 hasConceptScore W2405970994C142424586 @default.
• W2405970994 hasConceptScore W2405970994C159654299 @default.
• W2405970994 hasConceptScore W2405970994C177713679 @default.
• W2405970994 hasConceptScore W2405970994C203014093 @default.
• W2405970994 hasConceptScore W2405970994C2776694085 @default.
• W2405970994 hasConceptScore W2405970994C2777063308 @default.
• W2405970994 hasConceptScore W2405970994C2777628635 @default.
• W2405970994 hasConceptScore W2405970994C2777701055 @default.
• W2405970994 hasConceptScore W2405970994C2778384902 @default.
• W2405970994 hasConceptScore W2405970994C2779443120 @default.
• W2405970994 hasConceptScore W2405970994C2781300812 @default.
• W2405970994 hasConceptScore W2405970994C501593827 @default.
• W2405970994 hasConceptScore W2405970994C542903549 @default.
• W2405970994 hasConceptScore W2405970994C71924100 @default.

• next