FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2405979079> ?p ?o ?g. }

• W2405979079 abstract "Healthy aging is associated with decline of cognitive functions. However, even before those declines become noticeable, the neural architecture underlying those mechanisms has undergone considerable restructuring and reorganization. During performance of a cognitive task, not only have the task-relevant networks demonstrated reorganization with aging, which occurs primarily by recruitment of additional areas to preserve performance, but the task-irrelevant network of the “default-mode” network (DMN), which is normally deactivated during task performance, has also consistently shown reduction of this deactivation with aging. Here, we revisited those age-related changes in task-relevant (i.e. language system) and task-irrelevant (i.e. DMN) systems with a language production paradigm in terms of task-induced activation/deactivation, functional connectivity, and context-dependent correlations between the two systems. Our task fMRI data demonstrated a late increase in cortical recruitment in terms of extent of activation, only observable in our older healthy adult group, when compared to the younger healthy adult group, with recruitment of the contralateral hemisphere, but also other regions from the network previously underutilized. Our middle-aged individuals, when compared to the younger healthy adult group, presented lower levels of activation intensity and connectivity strength, with no recruitment of additional regions, possibly reflecting an initial, uncompensated, network decline. In contrast, the DMN presented a gradual decrease in deactivation intensity and deactivation extent (i.e. low in the middle-aged, and lower in the old) and similar gradual reduction of functional connectivity within the network, with no compensation. The patterns of age-related changes in the task-relevant system and DMN are incongruent with the previously suggested notion of anti-correlation of the two systems. The context-dependent correlation by psycho-physiological interaction (PPI) analysis demonstrated an independence of these two systems, with the onset of task not influencing the correlation between the two systems. Our results suggest that the language network and the DMN may be non-dependent systems, potentially correlated through the re-allocation of cortical resources, and that aging may affect those two systems differently." @default.
• W2405979079 created "2016-06-24" @default.
• W2405979079 creator A5017109545 @default.
• W2405979079 creator A5021076382 @default.
• W2405979079 creator A5022110697 @default.
• W2405979079 creator A5044020725 @default.
• W2405979079 creator A5059402802 @default.
• W2405979079 creator A5065156623 @default.
• W2405979079 creator A5067812949 @default.
• W2405979079 creator A5090108909 @default.
• W2405979079 date "2016-05-23" @default.
• W2405979079 modified "2023-10-15" @default.
• W2405979079 title "Age-Related Changes in BOLD Activation Pattern in Phonemic Fluency Paradigm: An Investigation of Activation, Functional Connectivity and Psychophysiological Interactions" @default.
• W2405979079 cites W1524356610 @default.
• W2405979079 cites W1542400270 @default.
• W2405979079 cites W1543904653 @default.
• W2405979079 cites W1795327044 @default.
• W2405979079 cites W1966798637 @default.
• W2405979079 cites W1969676672 @default.
• W2405979079 cites W1970695058 @default.
• W2405979079 cites W1981573523 @default.
• W2405979079 cites W1981685168 @default.
• W2405979079 cites W1991771535 @default.
• W2405979079 cites W2000539875 @default.
• W2405979079 cites W2012437345 @default.
• W2405979079 cites W2013391120 @default.
• W2405979079 cites W2023436080 @default.
• W2405979079 cites W2044134952 @default.
• W2405979079 cites W2051512482 @default.
• W2405979079 cites W2051884545 @default.
• W2405979079 cites W2056081184 @default.
• W2405979079 cites W2057988711 @default.
• W2405979079 cites W2061195971 @default.
• W2405979079 cites W2062440016 @default.
• W2405979079 cites W2065292719 @default.
• W2405979079 cites W2066517499 @default.
• W2405979079 cites W2070558694 @default.
• W2405979079 cites W2089725106 @default.
• W2405979079 cites W2095642798 @default.
• W2405979079 cites W2102783734 @default.
• W2405979079 cites W2103738604 @default.
• W2405979079 cites W2104897414 @default.
• W2405979079 cites W2105306137 @default.
• W2405979079 cites W2112005505 @default.
• W2405979079 cites W2114492421 @default.
• W2405979079 cites W2117140276 @default.
• W2405979079 cites W2119706526 @default.
• W2405979079 cites W2119792333 @default.
• W2405979079 cites W2120457869 @default.
• W2405979079 cites W2121747917 @default.
• W2405979079 cites W2121794894 @default.
• W2405979079 cites W2125386334 @default.
• W2405979079 cites W2125705043 @default.
• W2405979079 cites W2127495504 @default.
• W2405979079 cites W2130912823 @default.
• W2405979079 cites W2130930647 @default.
• W2405979079 cites W2131201125 @default.
• W2405979079 cites W2134435409 @default.
• W2405979079 cites W2135475851 @default.
• W2405979079 cites W2136022845 @default.
• W2405979079 cites W2136435696 @default.
• W2405979079 cites W2137730197 @default.
• W2405979079 cites W2139581313 @default.
• W2405979079 cites W2141302788 @default.
• W2405979079 cites W2144351977 @default.
• W2405979079 cites W2149389492 @default.
• W2405979079 cites W2159049822 @default.
• W2405979079 cites W2162010696 @default.
• W2405979079 cites W2162347612 @default.
• W2405979079 cites W2162654011 @default.
• W2405979079 cites W2164262344 @default.
• W2405979079 cites W2172513721 @default.
• W2405979079 cites W4230026655 @default.
• W2405979079 cites W4243115481 @default.
• W2405979079 cites W4376849352 @default.
• W2405979079 doi "https://doi.org/10.3389/fnagi.2016.00110" @default.
• W2405979079 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4876121" @default.
• W2405979079 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27242519" @default.
• W2405979079 hasPublicationYear "2016" @default.
• W2405979079 type Work @default.
• W2405979079 sameAs 2405979079 @default.
• W2405979079 citedByCount "11" @default.
• W2405979079 countsByYear W24059790792017 @default.
• W2405979079 countsByYear W24059790792018 @default.
• W2405979079 countsByYear W24059790792019 @default.
• W2405979079 countsByYear W24059790792020 @default.
• W2405979079 countsByYear W24059790792021 @default.
• W2405979079 countsByYear W24059790792023 @default.
• W2405979079 crossrefType "journal-article" @default.
• W2405979079 hasAuthorship W2405979079A5017109545 @default.
• W2405979079 hasAuthorship W2405979079A5021076382 @default.
• W2405979079 hasAuthorship W2405979079A5022110697 @default.
• W2405979079 hasAuthorship W2405979079A5044020725 @default.
• W2405979079 hasAuthorship W2405979079A5059402802 @default.
• W2405979079 hasAuthorship W2405979079A5065156623 @default.
• W2405979079 hasAuthorship W2405979079A5067812949 @default.
• W2405979079 hasAuthorship W2405979079A5090108909 @default.
• W2405979079 hasBestOaLocation W24059790791 @default.
• W2405979079 hasConcept C126322002 @default.
• W2405979079 hasConcept C141516989 @default.

• next