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- W2405994062 abstract "Hypoxia-inducible factor-1 (HIF-1) alpha activation following dysfunction of the von Hippel–Lindau (VHL) tumor suppressor gene is one of the major oncogenic pathways in renal-cell carcinoma. Temsirolimus, a mammalian target of rapamycin (mTOR) inhibitor, downregulates mTOR-dependent HIF-1 translation and was recently shown to prolong the overall and progression-free survival compared with interferon alpha in patients with advanced renal-cell carcinoma and poor prognostic factors. Here, we report the case of a patient with metastatic clear-cell renal-cell carcinoma who showed a dramatic, sustained response to temsirolimus after progression on sunitinib therapy. This report confirms the considerable anti-tumor effect of temsirolimus in clear-cell renal-cell carcinoma patients." @default.
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- W2405994062 date "2009-01-01" @default.
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- W2405994062 title "Sustained response of metastatic clear-cell renal-cell carcinoma to temsirolimus after sunitinib failure: A case report" @default.
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