Matches in SemOpenAlex for { <https://semopenalex.org/work/W2406001921> ?p ?o ?g. }
- W2406001921 abstract "Hedgehog signaling plays very important roles in development and cancers. Vertebrates have three transcriptional factors, Gli1, Gli2 and Gli3. Among them, Gli3 is a very special transcriptional factor which closely resembles Cubitus interruptus (Ci, in Drosophila) structurally and functionally as a ‘double agent’ for Shh target gene expression. Here we show that Gli3 full-length, but not the truncated form, can be methylated at K436 and K595. This methylation is specifically catalyzed by Set7, a lysine methyltransferase (KMT). Methylation at K436 and K595 respectively increases the stability and DNA binding ability of Gli3, resulting in an enhancement of Shh signaling activation. Furthermore, functional experiments indicate that the Gli3 methylation contributes to the tumor growth and metastasis in non-small cell lung cancer in vitro and in vivo. Therefore, we propose that Set7 mediated methylation is a novel PTM of Gli3, which positively regulates the transactivity of Gli3 and the activation of Shh signaling." @default.
- W2406001921 created "2016-06-24" @default.
- W2406001921 creator A5011117247 @default.
- W2406001921 creator A5032593625 @default.
- W2406001921 creator A5045356053 @default.
- W2406001921 creator A5059455652 @default.
- W2406001921 creator A5071798264 @default.
- W2406001921 creator A5076452725 @default.
- W2406001921 date "2016-05-05" @default.
- W2406001921 modified "2023-10-16" @default.
- W2406001921 title "Set7 mediated Gli3 methylation plays a positive role in the activation of Sonic Hedgehog pathway in mammals" @default.
- W2406001921 cites W1785629757 @default.
- W2406001921 cites W1821222874 @default.
- W2406001921 cites W1938204876 @default.
- W2406001921 cites W1974006656 @default.
- W2406001921 cites W1976522456 @default.
- W2406001921 cites W1978279515 @default.
- W2406001921 cites W1987821813 @default.
- W2406001921 cites W1988323955 @default.
- W2406001921 cites W1992868516 @default.
- W2406001921 cites W1994914575 @default.
- W2406001921 cites W2004305401 @default.
- W2406001921 cites W2011380521 @default.
- W2406001921 cites W2011540184 @default.
- W2406001921 cites W2013024419 @default.
- W2406001921 cites W2020808779 @default.
- W2406001921 cites W2023913877 @default.
- W2406001921 cites W2027728353 @default.
- W2406001921 cites W2032165583 @default.
- W2406001921 cites W2032205265 @default.
- W2406001921 cites W2035381044 @default.
- W2406001921 cites W2037199116 @default.
- W2406001921 cites W2037215281 @default.
- W2406001921 cites W2040365591 @default.
- W2406001921 cites W2043048836 @default.
- W2406001921 cites W2047771126 @default.
- W2406001921 cites W2049362317 @default.
- W2406001921 cites W2050307267 @default.
- W2406001921 cites W2063266633 @default.
- W2406001921 cites W2065277366 @default.
- W2406001921 cites W2066711817 @default.
- W2406001921 cites W2073042236 @default.
- W2406001921 cites W2080752012 @default.
- W2406001921 cites W2085607023 @default.
- W2406001921 cites W2090542192 @default.
- W2406001921 cites W2098176608 @default.
- W2406001921 cites W2103045139 @default.
- W2406001921 cites W2104726963 @default.
- W2406001921 cites W2108707301 @default.
- W2406001921 cites W2110588521 @default.
- W2406001921 cites W2120594989 @default.
- W2406001921 cites W2122294512 @default.
- W2406001921 cites W2131686724 @default.
- W2406001921 cites W2132749637 @default.
- W2406001921 cites W2134805019 @default.
- W2406001921 cites W2140381750 @default.
- W2406001921 cites W2147956780 @default.
- W2406001921 cites W2148931486 @default.
- W2406001921 cites W2160689782 @default.
- W2406001921 cites W2163007274 @default.
- W2406001921 cites W2163838718 @default.
- W2406001921 cites W2165257302 @default.
- W2406001921 doi "https://doi.org/10.7554/elife.15690" @default.
- W2406001921 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4884081" @default.
- W2406001921 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27146893" @default.
- W2406001921 hasPublicationYear "2016" @default.
- W2406001921 type Work @default.
- W2406001921 sameAs 2406001921 @default.
- W2406001921 citedByCount "46" @default.
- W2406001921 countsByYear W24060019212017 @default.
- W2406001921 countsByYear W24060019212018 @default.
- W2406001921 countsByYear W24060019212019 @default.
- W2406001921 countsByYear W24060019212020 @default.
- W2406001921 countsByYear W24060019212021 @default.
- W2406001921 countsByYear W24060019212022 @default.
- W2406001921 countsByYear W24060019212023 @default.
- W2406001921 crossrefType "journal-article" @default.
- W2406001921 hasAuthorship W2406001921A5011117247 @default.
- W2406001921 hasAuthorship W2406001921A5032593625 @default.
- W2406001921 hasAuthorship W2406001921A5045356053 @default.
- W2406001921 hasAuthorship W2406001921A5059455652 @default.
- W2406001921 hasAuthorship W2406001921A5071798264 @default.
- W2406001921 hasAuthorship W2406001921A5076452725 @default.
- W2406001921 hasBestOaLocation W24060019211 @default.
- W2406001921 hasConcept C104317684 @default.
- W2406001921 hasConcept C120407494 @default.
- W2406001921 hasConcept C145837895 @default.
- W2406001921 hasConcept C150194340 @default.
- W2406001921 hasConcept C158448853 @default.
- W2406001921 hasConcept C190727270 @default.
- W2406001921 hasConcept C2776637008 @default.
- W2406001921 hasConcept C2778539099 @default.
- W2406001921 hasConcept C2779933373 @default.
- W2406001921 hasConcept C33288867 @default.
- W2406001921 hasConcept C502942594 @default.
- W2406001921 hasConcept C54355233 @default.
- W2406001921 hasConcept C62478195 @default.
- W2406001921 hasConcept C86339819 @default.
- W2406001921 hasConcept C86803240 @default.
- W2406001921 hasConcept C88498014 @default.