Matches in SemOpenAlex for { <https://semopenalex.org/work/W2406003191> ?p ?o ?g. }
- W2406003191 endingPage "304" @default.
- W2406003191 startingPage "297" @default.
- W2406003191 abstract "We review the data available on the structure, developmental appearance and embryonic regulation of the tissue-specific transcription factor HNF1 alpha (LFB1) in Xenopus. The expression of the HNF1 alpha gene starts early in embryogenesis shortly after mid-blastula transition and the protein accumulates in the region of the embryo where liver, pronephros and gut--tissues that contain HNF1 alpha in the adult--are developing. The cofactor DCoH, known to stabilize dimer formation of HNF1 alpha, is present as a maternal factor in the egg and has a partially distinct tissue distribution compared to HNF1 alpha. This implies that DCoH does not only modulate HNF1 alpha dimerization but may also cooperate with other transcription factors. By injecting HNF1 alpha promoter CAT constructs into fertilized Xenopus eggs we obtained activation of the injected gene restricted to the region of the developing larvae expressing endogenous HNF1 alpha. Deletion analysis allowed to define the OZ-element that is essential for embryonic activation. This element also occurs in other promoters activated at mid-blastula transition in the embryo and interacts with the maternal factor OZ-1. As the HNF1 alpha promoter also contains functional binding sites for HNF4 and HNF1, we postulate that all of these transcription factors contribute to the cascade leading to proper embryonic activation of the HNF1 alpha gene." @default.
- W2406003191 created "2016-06-24" @default.
- W2406003191 creator A5006222046 @default.
- W2406003191 creator A5009237531 @default.
- W2406003191 creator A5021871287 @default.
- W2406003191 creator A5052001856 @default.
- W2406003191 creator A5053709388 @default.
- W2406003191 creator A5073052886 @default.
- W2406003191 creator A5077819259 @default.
- W2406003191 date "1996-02-01" @default.
- W2406003191 modified "2023-09-23" @default.
- W2406003191 title "Regulation and function of the tissue-specific transcription factor HNF1 alpha (LFB1) during Xenopus development." @default.
- W2406003191 cites W1464724343 @default.
- W2406003191 cites W1559932979 @default.
- W2406003191 cites W1941098794 @default.
- W2406003191 cites W1978272885 @default.
- W2406003191 cites W1978819530 @default.
- W2406003191 cites W2007812996 @default.
- W2406003191 cites W2009038758 @default.
- W2406003191 cites W2011957289 @default.
- W2406003191 cites W2016218459 @default.
- W2406003191 cites W2031030976 @default.
- W2406003191 cites W2062423659 @default.
- W2406003191 cites W2087288778 @default.
- W2406003191 cites W2087848618 @default.
- W2406003191 cites W2090467716 @default.
- W2406003191 cites W2099591248 @default.
- W2406003191 cites W2285547726 @default.
- W2406003191 cites W2407956519 @default.
- W2406003191 cites W2416610420 @default.
- W2406003191 cites W287412083 @default.
- W2406003191 cites W32813683 @default.
- W2406003191 cites W337785430 @default.
- W2406003191 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8735941" @default.
- W2406003191 hasPublicationYear "1996" @default.
- W2406003191 type Work @default.
- W2406003191 sameAs 2406003191 @default.
- W2406003191 citedByCount "5" @default.
- W2406003191 countsByYear W24060031912012 @default.
- W2406003191 countsByYear W24060031912016 @default.
- W2406003191 crossrefType "journal-article" @default.
- W2406003191 hasAuthorship W2406003191A5006222046 @default.
- W2406003191 hasAuthorship W2406003191A5009237531 @default.
- W2406003191 hasAuthorship W2406003191A5021871287 @default.
- W2406003191 hasAuthorship W2406003191A5052001856 @default.
- W2406003191 hasAuthorship W2406003191A5053709388 @default.
- W2406003191 hasAuthorship W2406003191A5073052886 @default.
- W2406003191 hasAuthorship W2406003191A5077819259 @default.
- W2406003191 hasConcept C101762097 @default.
- W2406003191 hasConcept C104317684 @default.
- W2406003191 hasConcept C121587040 @default.
- W2406003191 hasConcept C129536746 @default.
- W2406003191 hasConcept C150194340 @default.
- W2406003191 hasConcept C153911025 @default.
- W2406003191 hasConcept C196287685 @default.
- W2406003191 hasConcept C196843134 @default.
- W2406003191 hasConcept C2779535977 @default.
- W2406003191 hasConcept C54355233 @default.
- W2406003191 hasConcept C6047887 @default.
- W2406003191 hasConcept C63932345 @default.
- W2406003191 hasConcept C72699923 @default.
- W2406003191 hasConcept C86339819 @default.
- W2406003191 hasConcept C86803240 @default.
- W2406003191 hasConcept C87073359 @default.
- W2406003191 hasConcept C95444343 @default.
- W2406003191 hasConcept C99535661 @default.
- W2406003191 hasConceptScore W2406003191C101762097 @default.
- W2406003191 hasConceptScore W2406003191C104317684 @default.
- W2406003191 hasConceptScore W2406003191C121587040 @default.
- W2406003191 hasConceptScore W2406003191C129536746 @default.
- W2406003191 hasConceptScore W2406003191C150194340 @default.
- W2406003191 hasConceptScore W2406003191C153911025 @default.
- W2406003191 hasConceptScore W2406003191C196287685 @default.
- W2406003191 hasConceptScore W2406003191C196843134 @default.
- W2406003191 hasConceptScore W2406003191C2779535977 @default.
- W2406003191 hasConceptScore W2406003191C54355233 @default.
- W2406003191 hasConceptScore W2406003191C6047887 @default.
- W2406003191 hasConceptScore W2406003191C63932345 @default.
- W2406003191 hasConceptScore W2406003191C72699923 @default.
- W2406003191 hasConceptScore W2406003191C86339819 @default.
- W2406003191 hasConceptScore W2406003191C86803240 @default.
- W2406003191 hasConceptScore W2406003191C87073359 @default.
- W2406003191 hasConceptScore W2406003191C95444343 @default.
- W2406003191 hasConceptScore W2406003191C99535661 @default.
- W2406003191 hasIssue "1" @default.
- W2406003191 hasLocation W24060031911 @default.
- W2406003191 hasOpenAccess W2406003191 @default.
- W2406003191 hasPrimaryLocation W24060031911 @default.
- W2406003191 hasRelatedWork W1941098794 @default.
- W2406003191 hasRelatedWork W1974536305 @default.
- W2406003191 hasRelatedWork W1984889123 @default.
- W2406003191 hasRelatedWork W2023595128 @default.
- W2406003191 hasRelatedWork W2025982106 @default.
- W2406003191 hasRelatedWork W2050349489 @default.
- W2406003191 hasRelatedWork W2050471060 @default.
- W2406003191 hasRelatedWork W2106625155 @default.
- W2406003191 hasRelatedWork W2406003191 @default.
- W2406003191 hasRelatedWork W4254517284 @default.