Matches in SemOpenAlex for { <https://semopenalex.org/work/W2406118106> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2406118106 endingPage "4" @default.
- W2406118106 startingPage "1279" @default.
- W2406118106 abstract "The work described in this review addresses the multifunctional roles of growth factors and their cognate receptors in normal development and in tumorigenesis. The concept of epithelial cell plasticity is described in the context of embryonic development during which frequent remodeling occurs in epithelial tissues. The critical role of one member of the FGF family of growth factors is demonstrated in lung branching morphogenesis. Several members of this family have been shown to induce an epithelial-mesenchymal transition in a bladder carcinoma line. In vivo the same factors act in an autocrine or paracrine mode to favor tumor progression. It is suggested that an EGFR-ligand autocrine loop exerts a positive role in tumor progression of human bladder carcinoma whereas FGFR2 acts as a phenotypic tumor suppressor gene. Unexpectedly, constitutive activating mutations in FGFR3 have been uncovered in the majority of the Ta superficial tumors which progress only very rarely to the invasive stages. In contrast, in situ carcinoma, which are considered to be associated with a strong malignant potential, do not carry the FGFR3 mutations. The presence or absence of the mutations defines two distinct oncogenic pathways in bladder carcinogenesis. The studies reveal the complexities in defining the putative functions of growth factors at different times and differentiation stages during development and in tumor progression. These results emphasize the need for caution in the interpretation of studies evaluating the potential of novel anti-cancer agents and for better designs of in vitro and in vivo biological assays." @default.
- W2406118106 created "2016-06-24" @default.
- W2406118106 creator A5039283945 @default.
- W2406118106 date "2001-01-01" @default.
- W2406118106 modified "2023-09-23" @default.
- W2406118106 title "[Role of growth factor signaling in epithelial cell plasticity during development and in carcinogenesis]." @default.
- W2406118106 cites W120653960 @default.
- W2406118106 cites W150280984 @default.
- W2406118106 cites W1563019250 @default.
- W2406118106 cites W1801955451 @default.
- W2406118106 cites W1829274477 @default.
- W2406118106 cites W1850975011 @default.
- W2406118106 cites W1923939500 @default.
- W2406118106 cites W1964321121 @default.
- W2406118106 cites W1989228537 @default.
- W2406118106 cites W1991368761 @default.
- W2406118106 cites W2009257395 @default.
- W2406118106 cites W2031541885 @default.
- W2406118106 cites W2032103583 @default.
- W2406118106 cites W2047727235 @default.
- W2406118106 cites W2048837917 @default.
- W2406118106 cites W2060029591 @default.
- W2406118106 cites W2060447952 @default.
- W2406118106 cites W2067400935 @default.
- W2406118106 cites W2080988586 @default.
- W2406118106 cites W2093351885 @default.
- W2406118106 cites W2107535776 @default.
- W2406118106 cites W2113988225 @default.
- W2406118106 cites W2122722300 @default.
- W2406118106 cites W2122892477 @default.
- W2406118106 cites W2126684945 @default.
- W2406118106 cites W2137280750 @default.
- W2406118106 cites W2154524184 @default.
- W2406118106 cites W2163961175 @default.
- W2406118106 cites W2187340242 @default.
- W2406118106 cites W2189315483 @default.
- W2406118106 cites W2312752335 @default.
- W2406118106 cites W2314374552 @default.
- W2406118106 cites W2323702574 @default.
- W2406118106 cites W2326133032 @default.
- W2406118106 cites W2332835363 @default.
- W2406118106 cites W2415358958 @default.
- W2406118106 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11975324" @default.
- W2406118106 hasPublicationYear "2001" @default.
- W2406118106 type Work @default.
- W2406118106 sameAs 2406118106 @default.
- W2406118106 citedByCount "2" @default.
- W2406118106 crossrefType "journal-article" @default.
- W2406118106 hasAuthorship W2406118106A5039283945 @default.
- W2406118106 hasConcept C104317684 @default.
- W2406118106 hasConcept C121608353 @default.
- W2406118106 hasConcept C128240485 @default.
- W2406118106 hasConcept C170493617 @default.
- W2406118106 hasConcept C2779013556 @default.
- W2406118106 hasConcept C2779256057 @default.
- W2406118106 hasConcept C40692019 @default.
- W2406118106 hasConcept C502942594 @default.
- W2406118106 hasConcept C54355233 @default.
- W2406118106 hasConcept C555283112 @default.
- W2406118106 hasConcept C76419328 @default.
- W2406118106 hasConcept C7876069 @default.
- W2406118106 hasConcept C81885089 @default.
- W2406118106 hasConcept C86803240 @default.
- W2406118106 hasConcept C95444343 @default.
- W2406118106 hasConceptScore W2406118106C104317684 @default.
- W2406118106 hasConceptScore W2406118106C121608353 @default.
- W2406118106 hasConceptScore W2406118106C128240485 @default.
- W2406118106 hasConceptScore W2406118106C170493617 @default.
- W2406118106 hasConceptScore W2406118106C2779013556 @default.
- W2406118106 hasConceptScore W2406118106C2779256057 @default.
- W2406118106 hasConceptScore W2406118106C40692019 @default.
- W2406118106 hasConceptScore W2406118106C502942594 @default.
- W2406118106 hasConceptScore W2406118106C54355233 @default.
- W2406118106 hasConceptScore W2406118106C555283112 @default.
- W2406118106 hasConceptScore W2406118106C76419328 @default.
- W2406118106 hasConceptScore W2406118106C7876069 @default.
- W2406118106 hasConceptScore W2406118106C81885089 @default.
- W2406118106 hasConceptScore W2406118106C86803240 @default.
- W2406118106 hasConceptScore W2406118106C95444343 @default.
- W2406118106 hasIssue "7" @default.
- W2406118106 hasLocation W24061181061 @default.
- W2406118106 hasOpenAccess W2406118106 @default.
- W2406118106 hasPrimaryLocation W24061181061 @default.
- W2406118106 hasRelatedWork W1915337809 @default.
- W2406118106 hasRelatedWork W2008017868 @default.
- W2406118106 hasRelatedWork W2127618977 @default.
- W2406118106 hasRelatedWork W2168026694 @default.
- W2406118106 hasRelatedWork W2293521165 @default.
- W2406118106 hasRelatedWork W2328757094 @default.
- W2406118106 hasRelatedWork W2406118106 @default.
- W2406118106 hasRelatedWork W2487824964 @default.
- W2406118106 hasRelatedWork W2764166429 @default.
- W2406118106 hasRelatedWork W2808822996 @default.
- W2406118106 hasVolume "185" @default.
- W2406118106 isParatext "false" @default.
- W2406118106 isRetracted "false" @default.
- W2406118106 magId "2406118106" @default.
- W2406118106 workType "article" @default.