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- W2406264256 abstract "Background Although the incidence of inflammatory bowel diseases (IBD) in Japan has increased, the prevalence of celiac disease is considered very low with the lowest genetic disposition. IBD is reported as the most common comorbidity because of the high positive rate of serological celiac markers. The aim of this study was to examine the current incidence of celiac disease, especially in IBD patients in Japan, where both wheat consumption and incidence of IBD have increased. Methods A total of 172 patients with IBD and 190 controls in Japan were screened for serum antibody of tissue transglutaminase and deaminated gliadin peptide. In seropositive patients, HLA testing and upper gastrointestinal endoscopy with duodenal biopsy was performed. Some of the sero-positive patients started a gluten-restricted or unrestricted diet, and serological change was determined. Results The positivity of both serum antibodies was significantly higher in IBD and correlated with disease activity. However, no biopsy-defined or HLA-defined true celiac disease was found. A decrease in serum antibody titers was observed with a gluten-restricted diet. Conclusions Despite the increased incidence of IBD and high positivity for serum celiac antibody in Japanese IBD patients, no true-positive celiac disease was noted, suggesting the presence of gluten intolerance in these populations." @default.
- W2406264256 created "2016-06-24" @default.
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- W2406264256 date "2013-01-01" @default.
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- W2406264256 title "Prevalence of serum celiac antibody in patients with IBD in Japan Chikako WatanabeShunsuke KomotoRyota HokariChie KuriharaYoshikiyo Okada • Hideaki HozumiMasaaki HigashiyamaAtsushi SakurabaKengo TomitaYoshikazu Tsuzuki • Atsushi KawaguchiShigeaki NagaoSho OgataSoichiro Miura" @default.
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