Matches in SemOpenAlex for { <https://semopenalex.org/work/W2406264313> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2406264313 endingPage "33" @default.
- W2406264313 startingPage "128" @default.
- W2406264313 abstract "Imaging methods based on light detection are being increasingly used for the non-invasive assessment of tumour growth in animal models. In contrast with bioluminescence imaging, there are no studies assessing the use of macroscopic fluorescence imaging for the longitudinal monitoring of tumour growth in an orthotopic glioma mouse model. Glioma cells expressing the red-shifted fluorescent protein mKate2 were orthotopically implanted to NOD-rag mice and the tumour size estimated by macroscopic fluorescence imaging was compared to the tumour volume determined morphometrically. There was no significant correlation between the data obtained by non-invasive macroscopic fluorescence imaging and post mortem morphometry. In addition, the fluorescence imaging failed to detect a morphometrically verified difference in tumour volume between animals with tumours expressing a potential tumour suppressor gene and controls. The fluorescence signal was affected by the spatial pattern of tumour growth and substantially attenuated by the interfering brain tissue. Our results indicate that the fluorescence signal emitted by glioma cells reflected not only the tumour mass, but also its spatial distribution. Macroscopic planar FLI in an epi-illumination mode and a conventional source of excitation light therefore appears to be more suitable for semi-quantitative assessment of the tumour growth especially in the case of superficially located tumours rather than for precise volume estimation of the xenografts located deep within the brain tissue." @default.
- W2406264313 created "2016-06-24" @default.
- W2406264313 creator A5022915257 @default.
- W2406264313 creator A5027401553 @default.
- W2406264313 creator A5047142865 @default.
- W2406264313 creator A5083529815 @default.
- W2406264313 date "2012-01-01" @default.
- W2406264313 modified "2023-09-26" @default.
- W2406264313 title "Limitations of macroscopic fluorescence imaging for the estimation of tumour growth in an orthotopic glioma mouse model." @default.
- W2406264313 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22849863" @default.
- W2406264313 hasPublicationYear "2012" @default.
- W2406264313 type Work @default.
- W2406264313 sameAs 2406264313 @default.
- W2406264313 citedByCount "1" @default.
- W2406264313 countsByYear W24062643132019 @default.
- W2406264313 crossrefType "journal-article" @default.
- W2406264313 hasAuthorship W2406264313A5022915257 @default.
- W2406264313 hasAuthorship W2406264313A5027401553 @default.
- W2406264313 hasAuthorship W2406264313A5047142865 @default.
- W2406264313 hasAuthorship W2406264313A5083529815 @default.
- W2406264313 hasConcept C111335760 @default.
- W2406264313 hasConcept C120665830 @default.
- W2406264313 hasConcept C121332964 @default.
- W2406264313 hasConcept C142724271 @default.
- W2406264313 hasConcept C161997846 @default.
- W2406264313 hasConcept C2778227246 @default.
- W2406264313 hasConcept C502942594 @default.
- W2406264313 hasConcept C54009773 @default.
- W2406264313 hasConcept C54355233 @default.
- W2406264313 hasConcept C57477423 @default.
- W2406264313 hasConcept C71924100 @default.
- W2406264313 hasConcept C81885089 @default.
- W2406264313 hasConcept C86803240 @default.
- W2406264313 hasConcept C91881484 @default.
- W2406264313 hasConceptScore W2406264313C111335760 @default.
- W2406264313 hasConceptScore W2406264313C120665830 @default.
- W2406264313 hasConceptScore W2406264313C121332964 @default.
- W2406264313 hasConceptScore W2406264313C142724271 @default.
- W2406264313 hasConceptScore W2406264313C161997846 @default.
- W2406264313 hasConceptScore W2406264313C2778227246 @default.
- W2406264313 hasConceptScore W2406264313C502942594 @default.
- W2406264313 hasConceptScore W2406264313C54009773 @default.
- W2406264313 hasConceptScore W2406264313C54355233 @default.
- W2406264313 hasConceptScore W2406264313C57477423 @default.
- W2406264313 hasConceptScore W2406264313C71924100 @default.
- W2406264313 hasConceptScore W2406264313C81885089 @default.
- W2406264313 hasConceptScore W2406264313C86803240 @default.
- W2406264313 hasConceptScore W2406264313C91881484 @default.
- W2406264313 hasIssue "3" @default.
- W2406264313 hasLocation W24062643131 @default.
- W2406264313 hasOpenAccess W2406264313 @default.
- W2406264313 hasPrimaryLocation W24062643131 @default.
- W2406264313 hasRelatedWork W1486776188 @default.
- W2406264313 hasRelatedWork W1983716918 @default.
- W2406264313 hasRelatedWork W1987640349 @default.
- W2406264313 hasRelatedWork W2037038299 @default.
- W2406264313 hasRelatedWork W2037136004 @default.
- W2406264313 hasRelatedWork W2037375753 @default.
- W2406264313 hasRelatedWork W2038391554 @default.
- W2406264313 hasRelatedWork W2064950073 @default.
- W2406264313 hasRelatedWork W2065495407 @default.
- W2406264313 hasRelatedWork W2070882610 @default.
- W2406264313 hasRelatedWork W2089308963 @default.
- W2406264313 hasRelatedWork W2093068814 @default.
- W2406264313 hasRelatedWork W2106527139 @default.
- W2406264313 hasRelatedWork W2199795028 @default.
- W2406264313 hasRelatedWork W2318226143 @default.
- W2406264313 hasRelatedWork W2323543452 @default.
- W2406264313 hasRelatedWork W2396192717 @default.
- W2406264313 hasRelatedWork W2474633411 @default.
- W2406264313 hasRelatedWork W2799592892 @default.
- W2406264313 hasRelatedWork W3165583837 @default.
- W2406264313 hasVolume "58" @default.
- W2406264313 isParatext "false" @default.
- W2406264313 isRetracted "false" @default.
- W2406264313 magId "2406264313" @default.
- W2406264313 workType "article" @default.