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- W2406286514 abstract "Carcinogenic effect of N-butyl-N-butanol (4) nitrosamine (BBN) and its acetate (BBN-Ac) was studied in ACI/N rats. The possibility of iso-transplantation of the cancer thus formed was also studied.Fifty-seven male rats were divided into 5 groups as follows;Group A: 20ml of 0.01% BBN was given daily for 25 weeks.Group B: 4ml of 0.05% BBN daily and 20ml of water twice a week for 25 weeks.Group C: 20ml of 0.05% BBN daily for 25 weeks.Group D: 20ml of 0.06% BBN-Ac daily for 25 weeks.Group E: 20ml of water daily as a control.Thirty-eight to forty weeks after the beginning of the administration, urinary bladder, kidney, liver, lung and lymph nodes were examined histologically.In groups A, C and D, papillomatous tumors of the urinary bladder were found in all of the animals and 27%, 90% and 100% of them were identified as cancer, respectively. The nature of the cancer was the transitional cell carcinoma in most cases and some of them were accompanied with squamous cell metaplasia.In the group B, hyperplasia of mucous membrane, papilloma and papillary cancer of the urinary bladder were seen in 4, 8 and 1 (8%) cases, respectively. The low rate of the development of the cancer in this group seems to be contrary to the expectation that a limited water supply would result in a greater rate of the development of bladder cancer owing to a long retention of concentrated urine in the bladder.The bladder carcinomas were transplanted subcutaneouslly into ACI/N rats. Palpable tumors developed in one week and the recipients died in 12 to 117 days.Sub-transplantations were all successful and 5 lines of transitional cell carcinoma and 2 lines of transitional cell carcinoma accompanied with squamous cell metaplasia were thus established.One of the transitional cell carcinoma with squamous cell metaplasia was transplanted intraperitoneally. A similar successful result was obtained." @default.
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- W2406286514 date "1973-01-01" @default.
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- W2406286514 title "TRANSPLANTABILITY OF URINARY BLADDER CARCINOMAS INDUCED IN ACI/N RATS BY ORAL ADMINISTRATION OF N-BUTYL-N-BUTANOL (4) NITROSAMINE AND ITS ACETATE" @default.
- W2406286514 doi "https://doi.org/10.5980/jpnjurol1928.64.5_397" @default.
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