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• W2406287946 endingPage "e0155260" @default.
• W2406287946 startingPage "e0155260" @default.
• W2406287946 abstract "During orbital or interplanetary space flights, astronauts are exposed to cosmic radiations and microgravity. However, most earth-based studies on the potential health risks of space conditions have investigated the effects of these two conditions separately. This study aimed at assessing the combined effect of radiation exposure and microgravity on neuronal morphology and survival in vitro. In particular, we investigated the effects of simulated microgravity after acute (X-rays) or during chronic (Californium-252) exposure to ionizing radiation using mouse mature neuron cultures. Acute exposure to low (0.1 Gy) doses of X-rays caused a delay in neurite outgrowth and a reduction in soma size, while only the high dose impaired neuronal survival. Of interest, the strongest effect on neuronal morphology and survival was evident in cells exposed to microgravity and in particular in cells exposed to both microgravity and radiation. Removal of neurons from simulated microgravity for a period of 24 h was not sufficient to recover neurite length, whereas the soma size showed a clear re-adaptation to normal ground conditions. Genome-wide gene expression analysis confirmed a modulation of genes involved in neurite extension, cell survival and synaptic communication, suggesting that these changes might be responsible for the observed morphological effects. In general, the observed synergistic changes in neuronal network integrity and cell survival induced by simulated space conditions might help to better evaluate the astronaut's health risks and underline the importance of investigating the central nervous system and long-term cognition during and after a space flight." @default.
• W2406287946 created "2016-06-24" @default.
• W2406287946 creator A5003434078 @default.
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• W2406287946 date "2016-05-20" @default.
• W2406287946 modified "2023-10-17" @default.
• W2406287946 title "Combined Exposure to Simulated Microgravity and Acute or Chronic Radiation Reduces Neuronal Network Integrity and Survival" @default.
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• W2406287946 doi "https://doi.org/10.1371/journal.pone.0155260" @default.
• W2406287946 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4874625" @default.
• W2406287946 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27203085" @default.
• W2406287946 hasPublicationYear "2016" @default.
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