Matches in SemOpenAlex for { <https://semopenalex.org/work/W2406341440> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2406341440 endingPage "42" @default.
- W2406341440 startingPage "133" @default.
- W2406341440 abstract "To develop an active agent for skin whitening, the inhibitory effects of 285 plant extracts on tyrosinase activity were examined, and one plant extract having tyrosinase inhibition activity was chosen. Ramulus mori (young twigs of Morus alba L.) extracts showed inhibition activity in tyrosinase and melanin synthesis in B-16 melanoma cells. To clarify the mechanism of its inhibition on melanogenesis, the effect of R. mori extracts on tyrosinase activity, synthesis, and gene expression was evaluated. R. mori extracts showed tyrosinase inhibition activity by competitive method, and there was no suppression of tyrosinase synthesis and gene expression. Further, to evaluate the inhibitory activity of R. mori in vivo, its effect on melanin production in UV-induced brown guinea pigs was examined, where a decrease of melanin production in the guinea pig model was observed. Also, R. mori extracts showed no toxicity in animal tests such as the acute toxicity test, the skin irritation test, the eye irritation test, the skin sensitization test, and the acute oral toxicity test, and no toxicity in the human skin irritation test. A single compound from R. mori extracts was purified using various column chromatography and recrystallization, and its chemical structure was identified using mass chromatography, IR spectroscopy, and NMR analysis. The chemical structure was that of 2,3',4,5'-tetrahydroxystilbene(2-oxyresveratrol) and showed inhibition activity on tyrosinase (IC(50) = 0.23 microg/ml). Also, R. mori extracts inhibited tyrosinase activity in a competitive manner (Ki = 1.5 x 10(-6) M) when L-tyrosine was used as a substrate." @default.
- W2406341440 created "2016-06-24" @default.
- W2406341440 creator A5006232866 @default.
- W2406341440 creator A5033406279 @default.
- W2406341440 creator A5047601778 @default.
- W2406341440 creator A5081655120 @default.
- W2406341440 creator A5086443315 @default.
- W2406341440 creator A5089260639 @default.
- W2406341440 date "2003-04-26" @default.
- W2406341440 modified "2023-09-23" @default.
- W2406341440 title "Inhibitory effects of Ramulus mori extracts on melanogenesis." @default.
- W2406341440 cites W1644644959 @default.
- W2406341440 cites W1985729602 @default.
- W2406341440 cites W2067786533 @default.
- W2406341440 cites W21553369 @default.
- W2406341440 cites W2166819485 @default.
- W2406341440 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12715091" @default.
- W2406341440 hasPublicationYear "2003" @default.
- W2406341440 type Work @default.
- W2406341440 sameAs 2406341440 @default.
- W2406341440 citedByCount "11" @default.
- W2406341440 countsByYear W24063414402012 @default.
- W2406341440 countsByYear W24063414402013 @default.
- W2406341440 countsByYear W24063414402015 @default.
- W2406341440 countsByYear W24063414402018 @default.
- W2406341440 countsByYear W24063414402022 @default.
- W2406341440 crossrefType "journal-article" @default.
- W2406341440 hasAuthorship W2406341440A5006232866 @default.
- W2406341440 hasAuthorship W2406341440A5033406279 @default.
- W2406341440 hasAuthorship W2406341440A5047601778 @default.
- W2406341440 hasAuthorship W2406341440A5081655120 @default.
- W2406341440 hasAuthorship W2406341440A5086443315 @default.
- W2406341440 hasAuthorship W2406341440A5089260639 @default.
- W2406341440 hasConcept C107538193 @default.
- W2406341440 hasConcept C116263406 @default.
- W2406341440 hasConcept C150903083 @default.
- W2406341440 hasConcept C178790620 @default.
- W2406341440 hasConcept C181199279 @default.
- W2406341440 hasConcept C185592680 @default.
- W2406341440 hasConcept C202751555 @default.
- W2406341440 hasConcept C207001950 @default.
- W2406341440 hasConcept C2777752497 @default.
- W2406341440 hasConcept C2779078452 @default.
- W2406341440 hasConcept C29730261 @default.
- W2406341440 hasConcept C45904493 @default.
- W2406341440 hasConcept C55493867 @default.
- W2406341440 hasConcept C86803240 @default.
- W2406341440 hasConcept C87554066 @default.
- W2406341440 hasConcept C98274493 @default.
- W2406341440 hasConceptScore W2406341440C107538193 @default.
- W2406341440 hasConceptScore W2406341440C116263406 @default.
- W2406341440 hasConceptScore W2406341440C150903083 @default.
- W2406341440 hasConceptScore W2406341440C178790620 @default.
- W2406341440 hasConceptScore W2406341440C181199279 @default.
- W2406341440 hasConceptScore W2406341440C185592680 @default.
- W2406341440 hasConceptScore W2406341440C202751555 @default.
- W2406341440 hasConceptScore W2406341440C207001950 @default.
- W2406341440 hasConceptScore W2406341440C2777752497 @default.
- W2406341440 hasConceptScore W2406341440C2779078452 @default.
- W2406341440 hasConceptScore W2406341440C29730261 @default.
- W2406341440 hasConceptScore W2406341440C45904493 @default.
- W2406341440 hasConceptScore W2406341440C55493867 @default.
- W2406341440 hasConceptScore W2406341440C86803240 @default.
- W2406341440 hasConceptScore W2406341440C87554066 @default.
- W2406341440 hasConceptScore W2406341440C98274493 @default.
- W2406341440 hasIssue "2" @default.
- W2406341440 hasLocation W24063414401 @default.
- W2406341440 hasOpenAccess W2406341440 @default.
- W2406341440 hasPrimaryLocation W24063414401 @default.
- W2406341440 hasRelatedWork W1550461747 @default.
- W2406341440 hasRelatedWork W1964952304 @default.
- W2406341440 hasRelatedWork W2028982941 @default.
- W2406341440 hasRelatedWork W2040372670 @default.
- W2406341440 hasRelatedWork W2041579529 @default.
- W2406341440 hasRelatedWork W2124472391 @default.
- W2406341440 hasRelatedWork W2252577881 @default.
- W2406341440 hasRelatedWork W2406341440 @default.
- W2406341440 hasRelatedWork W2521024263 @default.
- W2406341440 hasRelatedWork W4210309715 @default.
- W2406341440 hasVolume "54" @default.
- W2406341440 isParatext "false" @default.
- W2406341440 isRetracted "false" @default.
- W2406341440 magId "2406341440" @default.
- W2406341440 workType "article" @default.