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- W2406423413 abstract "AbstractThe CACTA transposons, so named for a highly conserved motif at element ends, comprise one of the most abundant superfamilies of Class 2 (cut-and-paste) plant transposons. CACTA transposons characteristically include subterminal sequences of several hundred nucleotides containing closely spaced direct and inverted repeats of a short, conserved sequence of 14-15 bp. The Supressor-mutator (Spm) transposon, identified and subjected to detailed genetic analysis by Barbara McClintock, remains the paradigmatic element of the CACTA family. The Spm transposon encodes two proteins required for transposition, the transposase (TnpD) and a regulatory protein (TnpA) that binds to the subterminal repeats. Spm expression is subject to both genetic and epigenetic regulation. The Spm-encoded TnpA serves as an activator of the epigenetically inactivated, methylated Spm, stimulating both transient and heritable activation of the transposon. TnpA also serves as a negative regulator of the demethylated active element promoter and is required, in addition to the TnpD, for transposition.Key wordsCACTA elementstransposon Suppressor-mutator Spm transpositionTnpATnpDepigenetic regulation" @default.
- W2406423413 created "2016-06-24" @default.
- W2406423413 creator A5042977462 @default.
- W2406423413 date "2013-01-01" @default.
- W2406423413 modified "2023-09-25" @default.
- W2406423413 title "Molecular Genetics and Epigenetics of CACTA Elements" @default.
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- W2406423413 doi "https://doi.org/10.1007/978-1-62703-568-2_13" @default.
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