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- W2406460587 abstract "A dually crosslinked heparin-conjugated hyaluronan hydrogel (DCH) was synthesized for reinforcement and sustainably delivering growth factors in tissue engineering. Heparin-conjugated hyaluronan microgels after glycidyl methacrylation as reinforcing phase crosslinked with glycidyl-methacrylated hyaluronan as matrix phase by ultraviolet radiation. The morphology, water swelling ratio, rheological property, degradation, bone morphogenetic protein-2 (BMP-2) loading and delivery, and cytotoxicity were characterized. Increasing heparin content enhanced the loading and sustainable delivery of BMP-2, but partly attenuated the mechanical property of DCH that presented a much higher elastic modulus than bulk gel. The incorporation of heparin and dually crosslinked network was harmless to the good cytocompatibility of hyaluronan hydrogel." @default.
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- W2406460587 date "2016-05-21" @default.
- W2406460587 modified "2023-10-18" @default.
- W2406460587 title "Synthesis and characterization of a dually crosslinked heparin-conjugated HA hydrogel for BMP-2 sustained delivery" @default.
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- W2406460587 doi "https://doi.org/10.1080/00914037.2016.1180609" @default.
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