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- W2406562503 abstract "Unlike most other tumours, myeloma causes bone destruction without an osteoblastic reaction; we tried to assess whether myeloma secretes a humoral factor that inhibits osteoblasts. Human bone-derived cells were either co-cultured with myeloma cells, or cultured in medium conditioned by myeloma cells. Bone-derived cell growth was measured by cell counts and by uptake of tritiated thymidine (3H-Tdr); growth was inhibited when cultured in medium conditioned by myeloma cells and some inhibition was seen when the bone-derived cells were co-cultured with myeloma cells. The inhibiting effect was dose-dependent and also dependent upon the density of the myeloma cells conditioning the medium. The results of our study suggest that myeloma secretes an osteoblast inhibiting factor of less than 50,000 Dalton molecular weight." @default.
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- W2406562503 date "1989-03-01" @default.
- W2406562503 modified "2023-09-24" @default.
- W2406562503 title "Does myeloma secrete an osteoblast inhibiting factor?" @default.
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- W2406562503 doi "https://doi.org/10.1302/0301-620x.71b2.2925748" @default.
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