Matches in SemOpenAlex for { <https://semopenalex.org/work/W2406594013> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W2406594013 endingPage "93" @default.
- W2406594013 startingPage "185" @default.
- W2406594013 abstract "Factor D, an essential enzyme of the alternative pathway (AP) of complement, is eliminated by the kidney, and its plasma concentration increases 10-fold in end-stage renal disease (ESRD). The purpose of this study was to analyze the consequences of factor D accumulation. A number of in vitro assays were used to analyze AP activation in normal human serum (NHS), in normal serum supplemented with purified factor D to 10-fold its normal concentration (10 x D), and in sera of patients with ESRD. When compared with NHS, in 10 x D: 1) Spontaneous fluid-phase activation of complement at 37 degrees C was greatly increased as measured by C3 cleavage, 2) The lysis of rabbit erythrocytes, a function of the AP, was accelerated, 3) More C3 fragments bound to cuprophane membranes and to immune precipitates; both reactions were accompanied by the formation of more C5a, 4) Complement mediated solubilization of antigen-antibody precipitates was enhanced. Sera of patients with ESRD behaved similarly to 10 x D in all assays used, i.e., enhanced AP function, although complement activation measured in these assays varied widely from one individual to another. Thus, the elevated factor D concentration observed in renal failure might have important pathophysiological consequences, some of which could be detrimental (e.g., C5a produced during hemodialysis), while others might be beneficial, e.g., solubilization of immune precipitates." @default.
- W2406594013 created "2016-06-24" @default.
- W2406594013 creator A5034845209 @default.
- W2406594013 creator A5038351609 @default.
- W2406594013 creator A5044627513 @default.
- W2406594013 creator A5062245136 @default.
- W2406594013 creator A5063052056 @default.
- W2406594013 date "1989-10-01" @default.
- W2406594013 modified "2023-09-23" @default.
- W2406594013 title "Complement activation by the alternative pathway is modified in renal failure: the role of factor D." @default.
- W2406594013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2805459" @default.
- W2406594013 hasPublicationYear "1989" @default.
- W2406594013 type Work @default.
- W2406594013 sameAs 2406594013 @default.
- W2406594013 citedByCount "7" @default.
- W2406594013 countsByYear W24065940132022 @default.
- W2406594013 crossrefType "journal-article" @default.
- W2406594013 hasAuthorship W2406594013A5034845209 @default.
- W2406594013 hasAuthorship W2406594013A5038351609 @default.
- W2406594013 hasAuthorship W2406594013A5044627513 @default.
- W2406594013 hasAuthorship W2406594013A5062245136 @default.
- W2406594013 hasAuthorship W2406594013A5063052056 @default.
- W2406594013 hasConcept C111684460 @default.
- W2406594013 hasConcept C126322002 @default.
- W2406594013 hasConcept C134018914 @default.
- W2406594013 hasConcept C159641895 @default.
- W2406594013 hasConcept C159654299 @default.
- W2406594013 hasConcept C182629451 @default.
- W2406594013 hasConcept C189446657 @default.
- W2406594013 hasConcept C203014093 @default.
- W2406594013 hasConcept C2778063415 @default.
- W2406594013 hasConcept C71924100 @default.
- W2406594013 hasConcept C8891405 @default.
- W2406594013 hasConceptScore W2406594013C111684460 @default.
- W2406594013 hasConceptScore W2406594013C126322002 @default.
- W2406594013 hasConceptScore W2406594013C134018914 @default.
- W2406594013 hasConceptScore W2406594013C159641895 @default.
- W2406594013 hasConceptScore W2406594013C159654299 @default.
- W2406594013 hasConceptScore W2406594013C182629451 @default.
- W2406594013 hasConceptScore W2406594013C189446657 @default.
- W2406594013 hasConceptScore W2406594013C203014093 @default.
- W2406594013 hasConceptScore W2406594013C2778063415 @default.
- W2406594013 hasConceptScore W2406594013C71924100 @default.
- W2406594013 hasConceptScore W2406594013C8891405 @default.
- W2406594013 hasIssue "4" @default.
- W2406594013 hasLocation W24065940131 @default.
- W2406594013 hasOpenAccess W2406594013 @default.
- W2406594013 hasPrimaryLocation W24065940131 @default.
- W2406594013 hasRelatedWork W1514874279 @default.
- W2406594013 hasRelatedWork W1539816486 @default.
- W2406594013 hasRelatedWork W1973996890 @default.
- W2406594013 hasRelatedWork W2026099298 @default.
- W2406594013 hasRelatedWork W2047616366 @default.
- W2406594013 hasRelatedWork W2099753237 @default.
- W2406594013 hasRelatedWork W2104240978 @default.
- W2406594013 hasRelatedWork W2114198497 @default.
- W2406594013 hasRelatedWork W2249183785 @default.
- W2406594013 hasRelatedWork W143264506 @default.
- W2406594013 hasVolume "32" @default.
- W2406594013 isParatext "false" @default.
- W2406594013 isRetracted "false" @default.
- W2406594013 magId "2406594013" @default.
- W2406594013 workType "article" @default.