Matches in SemOpenAlex for { <https://semopenalex.org/work/W2406608300> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W2406608300 endingPage "183" @default.
- W2406608300 startingPage "175" @default.
- W2406608300 abstract "Tumor necrosis factor-α (TNF-α) plays a fundamental role in the initiation and persistence of skin inflammation in psoriasis. The best evidence of the essential activity of this cytokine in the pathogenesis of psoriasis came from the observation that selective TNF-α blockers are dramatically effective in the therapy of this disease. The TNF-α inhibitors, infliximab and etanercept, have been employed with success in moderate to severe psoriasis and in psoriatic arthritis in randomized controlled trials. Anti-TNF-α biologicals induce rapid disease resolution and long-lasting remission, suggesting that they may alter the natural course of the disease. Further studies are warranted to more precisely establish the biological bases of the action of anti-TNF-α agents, better define which subgroup of patients can benefit most from this treatment, and the modalities of combination therapy with other antipsoriatic agents. Many other TNF-α inhibitors have been developed but none of them has been yet used in the therapy of psoriasis. Major limitations to the use of selective TNF-α blockers include the reactivation of latent tuberculosis, the risk of opportunistic infections, the development of specific antibodies, which is associated with a reduced duration of response to treatment, and the high cost. Keywords: psoriasis, infliximab, etanercept, cdp870, adalimumab" @default.
- W2406608300 created "2016-06-24" @default.
- W2406608300 creator A5016818733 @default.
- W2406608300 creator A5050883859 @default.
- W2406608300 creator A5051419586 @default.
- W2406608300 creator A5087192032 @default.
- W2406608300 date "2004-06-01" @default.
- W2406608300 modified "2023-10-18" @default.
- W2406608300 title "Targeting Tumor Necrosis Factor-α in the Therapy of Psoriasis" @default.
- W2406608300 doi "https://doi.org/10.2174/1568010043343903" @default.
- W2406608300 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15180471" @default.
- W2406608300 hasPublicationYear "2004" @default.
- W2406608300 type Work @default.
- W2406608300 sameAs 2406608300 @default.
- W2406608300 citedByCount "42" @default.
- W2406608300 countsByYear W24066083002012 @default.
- W2406608300 countsByYear W24066083002014 @default.
- W2406608300 countsByYear W24066083002015 @default.
- W2406608300 countsByYear W24066083002017 @default.
- W2406608300 countsByYear W24066083002018 @default.
- W2406608300 countsByYear W24066083002019 @default.
- W2406608300 countsByYear W24066083002020 @default.
- W2406608300 countsByYear W24066083002021 @default.
- W2406608300 countsByYear W24066083002022 @default.
- W2406608300 countsByYear W24066083002023 @default.
- W2406608300 crossrefType "journal-article" @default.
- W2406608300 hasAuthorship W2406608300A5016818733 @default.
- W2406608300 hasAuthorship W2406608300A5050883859 @default.
- W2406608300 hasAuthorship W2406608300A5051419586 @default.
- W2406608300 hasAuthorship W2406608300A5087192032 @default.
- W2406608300 hasConcept C126322002 @default.
- W2406608300 hasConcept C17991360 @default.
- W2406608300 hasConcept C203014093 @default.
- W2406608300 hasConcept C2776215756 @default.
- W2406608300 hasConcept C2776260265 @default.
- W2406608300 hasConcept C2777138892 @default.
- W2406608300 hasConcept C2777226972 @default.
- W2406608300 hasConcept C2779134260 @default.
- W2406608300 hasConcept C2780132546 @default.
- W2406608300 hasConcept C2780564577 @default.
- W2406608300 hasConcept C71924100 @default.
- W2406608300 hasConceptScore W2406608300C126322002 @default.
- W2406608300 hasConceptScore W2406608300C17991360 @default.
- W2406608300 hasConceptScore W2406608300C203014093 @default.
- W2406608300 hasConceptScore W2406608300C2776215756 @default.
- W2406608300 hasConceptScore W2406608300C2776260265 @default.
- W2406608300 hasConceptScore W2406608300C2777138892 @default.
- W2406608300 hasConceptScore W2406608300C2777226972 @default.
- W2406608300 hasConceptScore W2406608300C2779134260 @default.
- W2406608300 hasConceptScore W2406608300C2780132546 @default.
- W2406608300 hasConceptScore W2406608300C2780564577 @default.
- W2406608300 hasConceptScore W2406608300C71924100 @default.
- W2406608300 hasIssue "2" @default.
- W2406608300 hasLocation W24066083001 @default.
- W2406608300 hasLocation W24066083002 @default.
- W2406608300 hasOpenAccess W2406608300 @default.
- W2406608300 hasPrimaryLocation W24066083001 @default.
- W2406608300 hasRelatedWork W1569618141 @default.
- W2406608300 hasRelatedWork W2075153701 @default.
- W2406608300 hasRelatedWork W2162495586 @default.
- W2406608300 hasRelatedWork W2236197927 @default.
- W2406608300 hasRelatedWork W2517819798 @default.
- W2406608300 hasRelatedWork W2755604283 @default.
- W2406608300 hasRelatedWork W2980843199 @default.
- W2406608300 hasRelatedWork W34188190 @default.
- W2406608300 hasRelatedWork W349538995 @default.
- W2406608300 hasRelatedWork W4253864806 @default.
- W2406608300 hasVolume "3" @default.
- W2406608300 isParatext "false" @default.
- W2406608300 isRetracted "false" @default.
- W2406608300 magId "2406608300" @default.
- W2406608300 workType "article" @default.