Matches in SemOpenAlex for { <https://semopenalex.org/work/W2406710395> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W2406710395 endingPage "36" @default.
- W2406710395 startingPage "1329" @default.
- W2406710395 abstract "We have previously reported the characterization of an intraperitoneally (IP) transplantable bone-forming MXT tumor. However, the question was unresolved as whether the bone-forming cells originated from either the host animal or from the neoplasm itself. The present work attempts to answer this question by studying the influences of inoculation sites (subcutaneously, SC; intraperitoneally, IP; in the brain, IB; intracranially, ICR) on both the cartilage- and bone-forming tumor phenotypes. Furthermore the influence of cell culture procedures (two- and three- dimensional cultures) on these phenotypes was investigated. SC administered MXT cancer cells never produce bone-forming tumors, suggesting the existence in the dermis of substance(s) inhibitory to the formation of cartilage or bone. On the contrary, our data clearly demonstrate that bone-forming tumors can be obtained by either IP route, in a way which mimics endochondral ossification, or in the brain (IB), a region usually devoid of connective tissue. This observation substantiates the hypothesis according to which the tumor itself is able to produce osseous tissue. Another main finding is the increasing occurrence of skeletal tissues produced by cells proceeding from three-dimensional culture. Finally, ICR and IB tumors exerted a bone-lytic action against the host skull suggesting that tumor cells either produce osteolytic substances (prostaglandins, enzymes) and/or that they contain various cell types exhibiting different properties toward osteogenesis. This model offers new perspectives for studying the mechanisms of both normal and pathologic osteogenesis." @default.
- W2406710395 created "2016-06-24" @default.
- W2406710395 creator A5001188276 @default.
- W2406710395 creator A5029125725 @default.
- W2406710395 creator A5031096807 @default.
- W2406710395 creator A5033613763 @default.
- W2406710395 creator A5055174396 @default.
- W2406710395 creator A5061199542 @default.
- W2406710395 date "1986-11-01" @default.
- W2406710395 modified "2023-10-16" @default.
- W2406710395 title "Influence of inoculation sites and tumor cell culture techniques on the phenotype of a mixed cartilage- and bone-producing mouse mammary tumor." @default.
- W2406710395 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3813489" @default.
- W2406710395 hasPublicationYear "1986" @default.
- W2406710395 type Work @default.
- W2406710395 sameAs 2406710395 @default.
- W2406710395 citedByCount "1" @default.
- W2406710395 crossrefType "journal-article" @default.
- W2406710395 hasAuthorship W2406710395A5001188276 @default.
- W2406710395 hasAuthorship W2406710395A5029125725 @default.
- W2406710395 hasAuthorship W2406710395A5031096807 @default.
- W2406710395 hasAuthorship W2406710395A5033613763 @default.
- W2406710395 hasAuthorship W2406710395A5055174396 @default.
- W2406710395 hasAuthorship W2406710395A5061199542 @default.
- W2406710395 hasConcept C105702510 @default.
- W2406710395 hasConcept C133605539 @default.
- W2406710395 hasConcept C142724271 @default.
- W2406710395 hasConcept C17938293 @default.
- W2406710395 hasConcept C202751555 @default.
- W2406710395 hasConcept C2777624698 @default.
- W2406710395 hasConcept C2779918246 @default.
- W2406710395 hasConcept C2780550940 @default.
- W2406710395 hasConcept C2780635560 @default.
- W2406710395 hasConcept C54355233 @default.
- W2406710395 hasConcept C71924100 @default.
- W2406710395 hasConcept C86803240 @default.
- W2406710395 hasConcept C95444343 @default.
- W2406710395 hasConceptScore W2406710395C105702510 @default.
- W2406710395 hasConceptScore W2406710395C133605539 @default.
- W2406710395 hasConceptScore W2406710395C142724271 @default.
- W2406710395 hasConceptScore W2406710395C17938293 @default.
- W2406710395 hasConceptScore W2406710395C202751555 @default.
- W2406710395 hasConceptScore W2406710395C2777624698 @default.
- W2406710395 hasConceptScore W2406710395C2779918246 @default.
- W2406710395 hasConceptScore W2406710395C2780550940 @default.
- W2406710395 hasConceptScore W2406710395C2780635560 @default.
- W2406710395 hasConceptScore W2406710395C54355233 @default.
- W2406710395 hasConceptScore W2406710395C71924100 @default.
- W2406710395 hasConceptScore W2406710395C86803240 @default.
- W2406710395 hasConceptScore W2406710395C95444343 @default.
- W2406710395 hasIssue "6" @default.
- W2406710395 hasLocation W24067103951 @default.
- W2406710395 hasOpenAccess W2406710395 @default.
- W2406710395 hasPrimaryLocation W24067103951 @default.
- W2406710395 hasRelatedWork W1484937317 @default.
- W2406710395 hasRelatedWork W1524812740 @default.
- W2406710395 hasRelatedWork W2001222030 @default.
- W2406710395 hasRelatedWork W2049484731 @default.
- W2406710395 hasRelatedWork W2061367688 @default.
- W2406710395 hasRelatedWork W2068709160 @default.
- W2406710395 hasRelatedWork W2088300488 @default.
- W2406710395 hasRelatedWork W2406710395 @default.
- W2406710395 hasRelatedWork W4250920118 @default.
- W2406710395 hasRelatedWork W2290965764 @default.
- W2406710395 hasVolume "6" @default.
- W2406710395 isParatext "false" @default.
- W2406710395 isRetracted "false" @default.
- W2406710395 magId "2406710395" @default.
- W2406710395 workType "article" @default.