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- W2406760917 abstract "Objective To evaluate the treatment responses of persistent allergic rhinitis with and without nasal discharge eosinophilia （EOS） to inhaled glucocorticosteroid （CS）, and therefore to verify whether low nasal discharge eosinophils predict poor response to treatment with CS. Methods Forty-two symptomatic allergic rhinitis patients, who had not received CS therapy in three months preceding the study, were examined before and 2 month, 4 months and 6 months after treatment with CS. At each visit, all patients underwent symptom scoring and physical sign scoring. The level of eosinophil cationic protein （ECP） in the nasal discharge supernatants was measured by radioimmunoassay. The patients were divided into 2 groups according to nasal discharge EOS percentages, an EOS group（ group A , EOS≥0. 03） and a non-EOS group （ group B, EOS 0. 05 ）, but the ECP level improved （ F = 3.78, P < 0. 05 ）. and the average daily dose of CS wear not different between the two groups at any visits. Conclusions In persistent allergic rhinitis with low nasal discharge EOS, CS therapy for 6 months failed to improve symptom and physical sign.Key words: Rhinitis, allergic, perennial; Glucocorticoids; Eosinophils; Eosinophil cationic protein" @default.
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- W2406760917 date "2009-03-01" @default.
- W2406760917 modified "2023-09-22" @default.
- W2406760917 title "Relationship between nasal discharge eosinophils and responses to treatment of inhaled glucocorticosteroid in patients with allergic rhinitis" @default.
- W2406760917 doi "https://doi.org/10.3760/cma.j.issn.1673-0860.2009.03.007" @default.
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