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• W2406874593 abstract "The present aims were firstly to coat metal implant material with a quorum sensing inhibitory thiophenone molecule, and secondly to assess the inhibitory effect on Staphylococcus epidermidis biofilm accumulation on thiophenone‐coated coupons. Thiophenone‐ and control‐coated metal coupons were prepared by silane hydrolysis and dip coating. The linking of thiophenone to the surface was confirmed by X‐ray photoelectron spectroscopy analyses. Biofilm by Staph. epidermidis, a frequent cause of implant‐associated infections, was allowed to form under flowing conditions for 48 h. The biofilm accumulations were significantly reduced on the thiophenone‐coated coupons. This was confirmed by confocal scanning microscopy. This study showed for the first time how a synthetic thiophenone may be covalently linked to a stainless steel surface, and that biofilm accumulations on such surfaces are significantly reduced. Functionalizing surfaces by covalent linking of thiophenones might open a wide array of applications. Thiophenone coating of medical implants represents a novel and promising approach to prevent implant‐associated infections." @default.
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• W2406874593 date "2016-07-19" @default.
• W2406874593 modified "2023-09-24" @default.
• W2406874593 title "<i>Staphylococcus epidermidis</i> biofilm on implant material is reduced by a covalently linked thiophenone" @default.
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• W2406874593 doi "https://doi.org/10.1111/jam.13188" @default.
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