FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2406914149> ?p ?o ?g. }

• W2406914149 endingPage "8" @default.
• W2406914149 startingPage "10130" @default.
• W2406914149 abstract "Deregulation of SOX9 expression has been detected in various human cancer tissues; however, the functional role of SOX9 expression has not been fully elucidated in glioma. SOX9 expression in glioma tissues was analyzed using public tumor datasets and quantitative reverse transcription polymerase chain reaction. The association of SOX9 expression with clinical prognosis in glioma patients was analyzed by examining publically available microarray profiling datasets. The functional roles of SOX9 in glioma were examined using gene set enrichment analysis (GSEA). Cell growth was measured using soft agar colony formation assay, and the cell cycle was analyzed using flow cytometry. Our data showed that SOX9 expression was commonly upregulated in glioma tissues, and patients with high SOX9 levels had shorter survival times. GSEA identified that the gene sets regulating cell proliferation and cell cycle progression were significantly enriched in glioma cells with high SOX9 expression. SOX9 downregulation decreased cyclin D1, CDK4 expression and Rb phosphorylation, which correlated with a reduced population of cells in the S phase and suppressed growth. SOX9, as an oncogene, is highly expressed in gliomas and may be potential indicators of a poor prognosis in glioma patients. SOX9 knockdown may suppress cancer cell growth by inducing cell cycle arrest, which suggests that SOX9 is a potential therapeutic target in glioma." @default.
• W2406914149 created "2016-06-24" @default.
• W2406914149 creator A5006385350 @default.
• W2406914149 creator A5015184109 @default.
• W2406914149 creator A5068668862 @default.
• W2406914149 creator A5089081009 @default.
• W2406914149 date "2015-01-01" @default.
• W2406914149 modified "2023-10-16" @default.
• W2406914149 title "Decreased expression of SOX9 indicates a better prognosis and inhibits the growth of glioma cells by inducing cell cycle arrest." @default.
• W2406914149 cites W1542773988 @default.
• W2406914149 cites W1588933372 @default.
• W2406914149 cites W1893588436 @default.
• W2406914149 cites W1969479669 @default.
• W2406914149 cites W1973295687 @default.
• W2406914149 cites W2015050458 @default.
• W2406914149 cites W2022584463 @default.
• W2406914149 cites W2025917129 @default.
• W2406914149 cites W2030501983 @default.
• W2406914149 cites W2066068289 @default.
• W2406914149 cites W2071974785 @default.
• W2406914149 cites W2085778840 @default.
• W2406914149 cites W2096262427 @default.
• W2406914149 cites W2104983126 @default.
• W2406914149 cites W2119604030 @default.
• W2406914149 cites W2127823872 @default.
• W2406914149 cites W2130410032 @default.
• W2406914149 cites W2139280965 @default.
• W2406914149 cites W2141077390 @default.
• W2406914149 cites W2143070168 @default.
• W2406914149 cites W2158681922 @default.
• W2406914149 cites W2159231404 @default.
• W2406914149 cites W2159657346 @default.
• W2406914149 cites W2160382843 @default.
• W2406914149 cites W2165871546 @default.
• W2406914149 cites W2169981723 @default.
• W2406914149 cites W2170659948 @default.
• W2406914149 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4637535" @default.
• W2406914149 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26617720" @default.
• W2406914149 hasPublicationYear "2015" @default.
• W2406914149 type Work @default.
• W2406914149 sameAs 2406914149 @default.
• W2406914149 citedByCount "13" @default.
• W2406914149 countsByYear W24069141492016 @default.
• W2406914149 countsByYear W24069141492017 @default.
• W2406914149 countsByYear W24069141492018 @default.
• W2406914149 countsByYear W24069141492019 @default.
• W2406914149 countsByYear W24069141492021 @default.
• W2406914149 countsByYear W24069141492022 @default.
• W2406914149 crossrefType "journal-article" @default.
• W2406914149 hasAuthorship W2406914149A5006385350 @default.
• W2406914149 hasAuthorship W2406914149A5015184109 @default.
• W2406914149 hasAuthorship W2406914149A5068668862 @default.
• W2406914149 hasAuthorship W2406914149A5089081009 @default.
• W2406914149 hasConcept C104317684 @default.
• W2406914149 hasConcept C127561419 @default.
• W2406914149 hasConcept C1491633281 @default.
• W2406914149 hasConcept C150194340 @default.
• W2406914149 hasConcept C153911025 @default.
• W2406914149 hasConcept C173396325 @default.
• W2406914149 hasConcept C199649820 @default.
• W2406914149 hasConcept C199835354 @default.
• W2406914149 hasConcept C2778227246 @default.
• W2406914149 hasConcept C2778486617 @default.
• W2406914149 hasConcept C2781018059 @default.
• W2406914149 hasConcept C29537977 @default.
• W2406914149 hasConcept C502942594 @default.
• W2406914149 hasConcept C54355233 @default.
• W2406914149 hasConcept C553184892 @default.
• W2406914149 hasConcept C62112901 @default.
• W2406914149 hasConcept C81885089 @default.
• W2406914149 hasConcept C86803240 @default.
• W2406914149 hasConceptScore W2406914149C104317684 @default.
• W2406914149 hasConceptScore W2406914149C127561419 @default.
• W2406914149 hasConceptScore W2406914149C1491633281 @default.
• W2406914149 hasConceptScore W2406914149C150194340 @default.
• W2406914149 hasConceptScore W2406914149C153911025 @default.
• W2406914149 hasConceptScore W2406914149C173396325 @default.
• W2406914149 hasConceptScore W2406914149C199649820 @default.
• W2406914149 hasConceptScore W2406914149C199835354 @default.
• W2406914149 hasConceptScore W2406914149C2778227246 @default.
• W2406914149 hasConceptScore W2406914149C2778486617 @default.
• W2406914149 hasConceptScore W2406914149C2781018059 @default.
• W2406914149 hasConceptScore W2406914149C29537977 @default.
• W2406914149 hasConceptScore W2406914149C502942594 @default.
• W2406914149 hasConceptScore W2406914149C54355233 @default.
• W2406914149 hasConceptScore W2406914149C553184892 @default.
• W2406914149 hasConceptScore W2406914149C62112901 @default.
• W2406914149 hasConceptScore W2406914149C81885089 @default.
• W2406914149 hasConceptScore W2406914149C86803240 @default.
• W2406914149 hasIssue "9" @default.
• W2406914149 hasLocation W24069141491 @default.
• W2406914149 hasOpenAccess W2406914149 @default.
• W2406914149 hasPrimaryLocation W24069141491 @default.
• W2406914149 hasRelatedWork W1912716912 @default.
• W2406914149 hasRelatedWork W2406914149 @default.
• W2406914149 hasRelatedWork W2425930418 @default.
• W2406914149 hasRelatedWork W2494327966 @default.
• W2406914149 hasRelatedWork W2580761780 @default.

• next