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- W2406914216 abstract "Invariant natural killer T cells (iNKT) are rare but powerful immunoregulatory T cells, evolutionarily conserved and characterized in humans by an invariant TCR Vα24-Jα18 chain, paired with a diverse TCR Vβ11 chain. Unlike conventional T cells which require peptide antigens presented by classical MHC molecules for their development and activation, iNKT cell selection and activation requires interaction with the non-polymorphic, MHC class I–like molecule CD1d presenting glyco(lipid) antigens. Upon invariant TCR – CD1d engagement, iNKT cells are activated and rapidly produce large amounts of cytokines. iNKT cells are functionally diverse and, either as immunoregulatory or effector cells, they can engage with nearly all aspects of the innate or adaptive immune response. As such, they can modulate emerging immune responses relevant to pathogens, autoimmunity, cancer, and alloreactivity. Although the biology of iNKT cells has been extensively studied in mice, their contribution to the pathogenesis of human disease remains elusive. Nevertheless, recent clinical observations in conjunction with insights from preclinical work highlight their importance in the alloresponse associated with hematopoietic stem cell transplantation and provide the impetus for exploring the therapeutic potential of iNKT cells." @default.
- W2406914216 created "2016-06-24" @default.
- W2406914216 creator A5020025345 @default.
- W2406914216 creator A5053436027 @default.
- W2406914216 creator A5068584310 @default.
- W2406914216 date "2016-01-01" @default.
- W2406914216 modified "2023-10-14" @default.
- W2406914216 title "The Role of Invariant NKT Cells in Immunity" @default.
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