FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2407114911> ?p ?o ?g. }

• W2407114911 endingPage "361" @default.
• W2407114911 startingPage "353" @default.
• W2407114911 abstract "Although dilated cardiomyopathy (DCM) is often caused by viral infections, it frequently involves autoimmune mechanisms associated with particular HLA-DR and DQ alleles. Our homozygous HLA-DQ8Ab(0) transgenic mice in the BALB/c background (HLA-DQ8(BALB/c)-Tg) developed early and progressive fatal heart failure from 4 to 5 weeks of age. Clinical signs of the disease included cyanotic eyes, tachycardia with dyspnea (from pale to cyanotic limbs), and terminal whole body edema. Sick mice had extremely dilated hearts, enlarged liver and spleen, and pleural/peritoneal effusion. Histology of the heart showed extensive heart muscle destruction with signs of fibrosis. The autoimmune nature of the disease was shown by high titers of antimyosin antibodies in the sera and IgG deposits in sick heart muscles, as well as focal neutrophil, T cell, and macrophage infiltration of the heart muscle. The sera of the sick mice showed a granular staining pattern on sections of healthy heart muscle. Quantitative analyses of DCM-specific gene expression studies revealed that sets of genes are involved in inflammation, hypoxia, and fibrosis. Treatment with FTY720 (Fingolimod/Gilenya) protected animals from the development of cardiomyopathy. HLA-DQ8(BALB/c)-Tg mice represent a spontaneous autoimmune myocarditis model that may provide a useful tool for studying the autoimmune mechanism of DCM and testing immunosuppressive drugs." @default.
• W2407114911 created "2016-06-24" @default.
• W2407114911 creator A5015026965 @default.
• W2407114911 creator A5021374114 @default.
• W2407114911 creator A5023050154 @default.
• W2407114911 creator A5041940522 @default.
• W2407114911 creator A5042829081 @default.
• W2407114911 creator A5066507402 @default.
• W2407114911 creator A5087306198 @default.
• W2407114911 date "2016-09-01" @default.
• W2407114911 modified "2023-10-17" @default.
• W2407114911 title "FTY720 (Gilenya) treatment prevents spontaneous autoimmune myocarditis and dilated cardiomyopathy in transgenic HLA-DQ8-BALB/c mice" @default.
• W2407114911 cites W1562316060 @default.
• W2407114911 cites W1572915736 @default.
• W2407114911 cites W1716209079 @default.
• W2407114911 cites W1772246669 @default.
• W2407114911 cites W1969250152 @default.
• W2407114911 cites W1978723007 @default.
• W2407114911 cites W1979315495 @default.
• W2407114911 cites W1981053070 @default.
• W2407114911 cites W1981125871 @default.
• W2407114911 cites W1984156843 @default.
• W2407114911 cites W1984748893 @default.
• W2407114911 cites W1987224476 @default.
• W2407114911 cites W1993284685 @default.
• W2407114911 cites W2000217815 @default.
• W2407114911 cites W2001962749 @default.
• W2407114911 cites W2003617014 @default.
• W2407114911 cites W2014536907 @default.
• W2407114911 cites W2016064855 @default.
• W2407114911 cites W2024769197 @default.
• W2407114911 cites W2027990237 @default.
• W2407114911 cites W2029269323 @default.
• W2407114911 cites W2033789572 @default.
• W2407114911 cites W2034207354 @default.
• W2407114911 cites W2036751727 @default.
• W2407114911 cites W2044647565 @default.
• W2407114911 cites W2046174933 @default.
• W2407114911 cites W2046429382 @default.
• W2407114911 cites W2047177657 @default.
• W2407114911 cites W2059277480 @default.
• W2407114911 cites W2059784252 @default.
• W2407114911 cites W2069360041 @default.
• W2407114911 cites W2071803642 @default.
• W2407114911 cites W2075621166 @default.
• W2407114911 cites W2077532089 @default.
• W2407114911 cites W2090243702 @default.
• W2407114911 cites W2090483910 @default.
• W2407114911 cites W2098853737 @default.
• W2407114911 cites W2104403932 @default.
• W2407114911 cites W2104896504 @default.
• W2407114911 cites W2113313121 @default.
• W2407114911 cites W2128077798 @default.
• W2407114911 cites W2137055930 @default.
• W2407114911 cites W2140419562 @default.
• W2407114911 cites W2140489221 @default.
• W2407114911 cites W2144450174 @default.
• W2407114911 cites W2146350343 @default.
• W2407114911 cites W2152776328 @default.
• W2407114911 cites W2157996679 @default.
• W2407114911 cites W2158217645 @default.
• W2407114911 cites W2160597210 @default.
• W2407114911 cites W2162395010 @default.
• W2407114911 cites W2165568633 @default.
• W2407114911 cites W2325299978 @default.
• W2407114911 cites W2325935354 @default.
• W2407114911 cites W2338851528 @default.
• W2407114911 cites W2560367415 @default.
• W2407114911 cites W339377225 @default.
• W2407114911 cites W4296231508 @default.
• W2407114911 doi "https://doi.org/10.1016/j.carpath.2016.05.003" @default.
• W2407114911 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5372700" @default.
• W2407114911 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27288745" @default.
• W2407114911 hasPublicationYear "2016" @default.
• W2407114911 type Work @default.
• W2407114911 sameAs 2407114911 @default.
• W2407114911 citedByCount "3" @default.
• W2407114911 countsByYear W24071149112019 @default.
• W2407114911 countsByYear W24071149112020 @default.
• W2407114911 countsByYear W24071149112021 @default.
• W2407114911 crossrefType "journal-article" @default.
• W2407114911 hasAuthorship W2407114911A5015026965 @default.
• W2407114911 hasAuthorship W2407114911A5021374114 @default.
• W2407114911 hasAuthorship W2407114911A5023050154 @default.
• W2407114911 hasAuthorship W2407114911A5041940522 @default.
• W2407114911 hasAuthorship W2407114911A5042829081 @default.
• W2407114911 hasAuthorship W2407114911A5066507402 @default.
• W2407114911 hasAuthorship W2407114911A5087306198 @default.
• W2407114911 hasBestOaLocation W24071149112 @default.
• W2407114911 hasConcept C126322002 @default.
• W2407114911 hasConcept C142724271 @default.
• W2407114911 hasConcept C159654299 @default.
• W2407114911 hasConcept C203014093 @default.
• W2407114911 hasConcept C2776383484 @default.
• W2407114911 hasConcept C2778198053 @default.
• W2407114911 hasConcept C2778797674 @default.
• W2407114911 hasConcept C2779075594 @default.
• W2407114911 hasConcept C2780130043 @default.

• next