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- W2407118672 abstract "Eleven compounds were isolated from the methanol extract of the leaves of Solanum erianthum D. Don, including five α-linolenic acid analogs, α-linolenic acid (1), 13 S-hydroxy-9( Z),11( E)-octadecadienoic acid (2), 9S-hydroxy-10( E),12( Z), 15( Z)-octadectrienoic acid (3), 9( Z),11( E)-octadecadienoic acid (4), and octadecanoic acid (5); two benzofuran-type lactones, loliolide (6) and dihydroactinidiolide (7); two steroidal alkaloids, solasonine (8) and solamargine (9); a flavonol glycoside, camelliaside C (10); and a flavone, 5-methoxy-(3″,4″-dihydro-3″,4″-diacetoxy)-2″,2″-dimethylpyrano-(7,8:5″,6″)-flavone (11). Among these isolated compounds, 9 showed the most potent activity against HBsAg, with an IC 50 of 1.57 μM, followed by 8(IC 50 is 5.89 μM). In the testing against HBeAg, 11 was the only active compound with an IC 50 of 36.11 μM. Compound 9 also revealed strong inhibition of DNA replication towards HBV and its IC 50 was 2.17 μM. However, α-linolenic acid (1) showed a prominent selected index (SI), both in anti-HBsAg and inhibition of DNA replication with SI values of 7.75 and 7.18, respectively. This is the first report that unsaturated fatty acid 1, steroidal alkaloid glycoside 9 and flavone 11, all showed excellent activity against HBV. These results provide lead candidates in the development of anti-HBV drugs from natural sources." @default.
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- W2407118672 date "2012-02-01" @default.
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- W2407118672 title "Antihepatitis B Virus Constituents of <i>Solanum Erianthum</i>" @default.
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- W2407118672 doi "https://doi.org/10.1177/1934578x1200700205" @default.
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