Matches in SemOpenAlex for { <https://semopenalex.org/work/W2407131164> ?p ?o ?g. }
- W2407131164 endingPage "433" @default.
- W2407131164 startingPage "427" @default.
- W2407131164 abstract "TP53 gene mutations are present in more than half of all human cancers. The resulting proteins are mostly full-length with a single aminoacid change and are abundantly present in cancer cells. Some of mutant p53 proteins gain oncogenic activities through which actively contribute to the aberrant cell proliferation, increased resistance to apoptotic stimuli and ability to metastatize of cancer cells. Gain of function mutant p53 proteins can transcriptionally regulate the expression of a large plethora of target genes. This mainly occurs through the formation of oncogenic transcriptional competent complexes that include mutant p53 protein, known transcription factors, posttranslational modifiers and scaffold proteins. Mutant p53 protein can also transcriptionally regulate the expression of microRNAs, small non-coding RNAs that regulate gene expression at the posttranscriptional level. Each microRNA can putatively target the expression of hundred mRNAs and consequently impact on many cellular functions. Thus, gain of function mutant p53 proteins can exert their oncogenic activities through the modulation of both non-coding and coding regions of human genome." @default.
- W2407131164 created "2016-06-24" @default.
- W2407131164 creator A5006520548 @default.
- W2407131164 creator A5039373029 @default.
- W2407131164 creator A5047759445 @default.
- W2407131164 date "2014-06-07" @default.
- W2407131164 modified "2023-09-26" @default.
- W2407131164 title "microRNAs: short non-coding bullets of gain of function mutant p53 proteins" @default.
- W2407131164 cites W1640635403 @default.
- W2407131164 cites W1964278971 @default.
- W2407131164 cites W1965641017 @default.
- W2407131164 cites W1967342065 @default.
- W2407131164 cites W1972892962 @default.
- W2407131164 cites W1977485776 @default.
- W2407131164 cites W1978025728 @default.
- W2407131164 cites W1986756287 @default.
- W2407131164 cites W1987912339 @default.
- W2407131164 cites W1989125392 @default.
- W2407131164 cites W2002995168 @default.
- W2407131164 cites W2008945738 @default.
- W2407131164 cites W2008961465 @default.
- W2407131164 cites W2026570544 @default.
- W2407131164 cites W2028164074 @default.
- W2407131164 cites W2030354790 @default.
- W2407131164 cites W2031313517 @default.
- W2407131164 cites W2033581856 @default.
- W2407131164 cites W2034263444 @default.
- W2407131164 cites W2034330475 @default.
- W2407131164 cites W2036982851 @default.
- W2407131164 cites W2041383414 @default.
- W2407131164 cites W2042316019 @default.
- W2407131164 cites W2042848097 @default.
- W2407131164 cites W2043912950 @default.
- W2407131164 cites W2046014802 @default.
- W2407131164 cites W2047529648 @default.
- W2407131164 cites W2047596219 @default.
- W2407131164 cites W2050569275 @default.
- W2407131164 cites W2052853384 @default.
- W2407131164 cites W2054293105 @default.
- W2407131164 cites W2063375027 @default.
- W2407131164 cites W2065195919 @default.
- W2407131164 cites W206553970 @default.
- W2407131164 cites W2070206037 @default.
- W2407131164 cites W2073599728 @default.
- W2407131164 cites W2078590818 @default.
- W2407131164 cites W2080392221 @default.
- W2407131164 cites W2083669383 @default.
- W2407131164 cites W2088441464 @default.
- W2407131164 cites W2091161969 @default.
- W2407131164 cites W2094957670 @default.
- W2407131164 cites W2097262030 @default.
- W2407131164 cites W2098647609 @default.
- W2407131164 cites W2099987999 @default.
- W2407131164 cites W2103211592 @default.
- W2407131164 cites W2103230738 @default.
- W2407131164 cites W2103667864 @default.
- W2407131164 cites W2104985090 @default.
- W2407131164 cites W2109227959 @default.
- W2407131164 cites W2112396116 @default.
- W2407131164 cites W2112785261 @default.
- W2407131164 cites W2114499007 @default.
- W2407131164 cites W2115860567 @default.
- W2407131164 cites W2119707042 @default.
- W2407131164 cites W2122575917 @default.
- W2407131164 cites W2125545284 @default.
- W2407131164 cites W2135918756 @default.
- W2407131164 cites W2138068224 @default.
- W2407131164 cites W2139233441 @default.
- W2407131164 cites W2139986038 @default.
- W2407131164 cites W2148430424 @default.
- W2407131164 cites W2150144117 @default.
- W2407131164 cites W2150536104 @default.
- W2407131164 cites W2155954232 @default.
- W2407131164 cites W2156177833 @default.
- W2407131164 cites W2159038842 @default.
- W2407131164 cites W2164194749 @default.
- W2407131164 cites W2165011061 @default.
- W2407131164 cites W2170645943 @default.
- W2407131164 cites W2172142216 @default.
- W2407131164 cites W2323533322 @default.
- W2407131164 cites W2326044761 @default.
- W2407131164 cites W2334988436 @default.
- W2407131164 cites W2597632520 @default.
- W2407131164 doi "https://doi.org/10.18632/oncoscience.52" @default.
- W2407131164 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4284623" @default.
- W2407131164 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25594041" @default.
- W2407131164 hasPublicationYear "2014" @default.
- W2407131164 type Work @default.
- W2407131164 sameAs 2407131164 @default.
- W2407131164 citedByCount "18" @default.
- W2407131164 countsByYear W24071311642015 @default.
- W2407131164 countsByYear W24071311642016 @default.
- W2407131164 countsByYear W24071311642017 @default.
- W2407131164 countsByYear W24071311642018 @default.
- W2407131164 countsByYear W24071311642021 @default.
- W2407131164 crossrefType "journal-article" @default.
- W2407131164 hasAuthorship W2407131164A5006520548 @default.
- W2407131164 hasAuthorship W2407131164A5039373029 @default.