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• W2407136405 abstract "NOD2/RIPK2 signalling plays essential role in the modulation of innate and adaptive immunity in mammals. In this study, NOD2 was functionally characterized in zebrafish (Danio rerio), and its interaction with a receptor-interaction protein, RIPK2, and RLRs such as MDA5 and RIG-I, as well as the adaptor, MAVS was revealed in fish innate immunity. The expression of NOD2 and RIPK2 in ZF4 cells has been constitutive and can be induced by the infection of Edwardsiella tarda and SVCV. The NOD2 can sense MDP in PGN from Gram-negative and -positive bacteria. It is further revealed that the NOD2 and RIPK2 can activate NF-κB and IFN promoters, inducing significantly antiviral defense against SVCV infection. As observed in the reduced bacterial burden in RIPK2 overexpressed cells, RIPK2 also has a role in inhibiting the bacterial replication. The overexpression of NOD2 in zebrafish embryos resulted in the increase of immune gene expression, especially those encoding PRRs and cytokines involved in antiviral response such as MDA5, RIG-I, and type I IFNs, etc. Luciferase reporter assays and co-immunoprecipitation assays demonstrated that zebrafish NOD2 is associated with MDA5 and RIG-I in signalling pathway. In addition, it is further demonstrated that RIPK2 and MAVS in combination with NOD2 have an enhanced role in NOD2-mediated NF-κB and type I IFN activation. It is concluded that teleost fish NOD2 can not only sense MDP for activating innate immunity as reported in mammals, but can also interact with other PRRs to form a network in antiviral innate response." @default.
• W2407136405 created "2016-06-24" @default.
• W2407136405 creator A5013946471 @default.
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• W2407136405 date "2016-08-01" @default.
• W2407136405 modified "2023-10-14" @default.
• W2407136405 title "NOD2 in zebrafish functions in antibacterial and also antiviral responses via NF-κB, and also MDA5, RIG-I and MAVS" @default.
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• W2407136405 cites W1862243922 @default.
• W2407136405 cites W1966190731 @default.
• W2407136405 cites W1975870295 @default.
• W2407136405 cites W1984236622 @default.
• W2407136405 cites W1990735654 @default.
• W2407136405 cites W1995061985 @default.
• W2407136405 cites W1995744610 @default.
• W2407136405 cites W1998226066 @default.
• W2407136405 cites W2000542704 @default.
• W2407136405 cites W2007080834 @default.
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• W2407136405 cites W2012272570 @default.
• W2407136405 cites W2013433092 @default.
• W2407136405 cites W2027748180 @default.
• W2407136405 cites W2033403762 @default.
• W2407136405 cites W2037502650 @default.
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• W2407136405 doi "https://doi.org/10.1016/j.fsi.2016.05.031" @default.
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