Matches in SemOpenAlex for { <https://semopenalex.org/work/W2407144023> ?p ?o ?g. }
- W2407144023 abstract "Islet amyloidosis by IAPP contributes to pancreatic β-cell death in diabetes, but the nature of toxic IAPP species remains elusive. Using concurrent time-resolved biophysical and biological measurements, we define the toxic species produced during IAPP amyloid formation and link their properties to induction of rat INS-1 β-cell and murine islet toxicity. These globally flexible, low order oligomers upregulate pro-inflammatory markers and induce reactive oxygen species. They do not bind 1-anilnonaphthalene-8-sulphonic acid and lack extensive β-sheet structure. Aromatic interactions modulate, but are not required for toxicity. Not all IAPP oligomers are toxic; toxicity depends on their partially structured conformational states. Some anti-amyloid agents paradoxically prolong cytotoxicity by prolonging the lifetime of the toxic species. The data highlight the distinguishing properties of toxic IAPP oligomers and the common features that they share with toxic species reported for other amyloidogenic polypeptides, providing information for rational drug design to treat IAPP induced β-cell death." @default.
- W2407144023 created "2016-06-24" @default.
- W2407144023 creator A5005107545 @default.
- W2407144023 creator A5007603996 @default.
- W2407144023 creator A5011686325 @default.
- W2407144023 creator A5012947240 @default.
- W2407144023 creator A5020645811 @default.
- W2407144023 creator A5022637430 @default.
- W2407144023 creator A5029940424 @default.
- W2407144023 creator A5048712863 @default.
- W2407144023 creator A5049680513 @default.
- W2407144023 creator A5051886481 @default.
- W2407144023 creator A5057478287 @default.
- W2407144023 creator A5061469419 @default.
- W2407144023 creator A5065857864 @default.
- W2407144023 creator A5074195383 @default.
- W2407144023 creator A5088588174 @default.
- W2407144023 creator A5090366405 @default.
- W2407144023 date "2016-05-23" @default.
- W2407144023 modified "2023-10-16" @default.
- W2407144023 title "Time-resolved studies define the nature of toxic IAPP intermediates, providing insight for anti-amyloidosis therapeutics" @default.
- W2407144023 cites W1588092320 @default.
- W2407144023 cites W1970397636 @default.
- W2407144023 cites W1976554020 @default.
- W2407144023 cites W1976642495 @default.
- W2407144023 cites W1979528014 @default.
- W2407144023 cites W1981793913 @default.
- W2407144023 cites W1982046448 @default.
- W2407144023 cites W1988583668 @default.
- W2407144023 cites W1990269304 @default.
- W2407144023 cites W1991356605 @default.
- W2407144023 cites W1992430893 @default.
- W2407144023 cites W1992722956 @default.
- W2407144023 cites W1993121159 @default.
- W2407144023 cites W1993553556 @default.
- W2407144023 cites W1993702167 @default.
- W2407144023 cites W1993935900 @default.
- W2407144023 cites W1995075732 @default.
- W2407144023 cites W1999909300 @default.
- W2407144023 cites W2000483769 @default.
- W2407144023 cites W2001629328 @default.
- W2407144023 cites W2005754586 @default.
- W2407144023 cites W2007236469 @default.
- W2407144023 cites W2008884445 @default.
- W2407144023 cites W2009623261 @default.
- W2407144023 cites W2011139454 @default.
- W2407144023 cites W2011426269 @default.
- W2407144023 cites W2013780997 @default.
- W2407144023 cites W2014829858 @default.
- W2407144023 cites W2015219413 @default.
- W2407144023 cites W2015684005 @default.
- W2407144023 cites W2018821716 @default.
- W2407144023 cites W2019799380 @default.
- W2407144023 cites W2024941512 @default.
- W2407144023 cites W2025447674 @default.
- W2407144023 cites W2026380581 @default.
- W2407144023 cites W2028109362 @default.
- W2407144023 cites W2029292770 @default.
- W2407144023 cites W2031173385 @default.
- W2407144023 cites W2032487213 @default.
- W2407144023 cites W2033484052 @default.
- W2407144023 cites W2034946303 @default.
- W2407144023 cites W2038108326 @default.
- W2407144023 cites W2038392139 @default.
- W2407144023 cites W2038438971 @default.
- W2407144023 cites W2038442365 @default.
- W2407144023 cites W2043833442 @default.
- W2407144023 cites W2044246569 @default.
- W2407144023 cites W2046855344 @default.
- W2407144023 cites W2046974636 @default.
- W2407144023 cites W2049562138 @default.
- W2407144023 cites W2053884409 @default.
- W2407144023 cites W2056410662 @default.
- W2407144023 cites W2061111679 @default.
- W2407144023 cites W2064367582 @default.
- W2407144023 cites W2067820229 @default.
- W2407144023 cites W2070114315 @default.
- W2407144023 cites W2082400315 @default.
- W2407144023 cites W2082592680 @default.
- W2407144023 cites W2082923159 @default.
- W2407144023 cites W2084280842 @default.
- W2407144023 cites W2086026855 @default.
- W2407144023 cites W2088065392 @default.
- W2407144023 cites W2089464893 @default.
- W2407144023 cites W2093861673 @default.
- W2407144023 cites W2096121410 @default.
- W2407144023 cites W2097259690 @default.
- W2407144023 cites W2101731922 @default.
- W2407144023 cites W2106201112 @default.
- W2407144023 cites W2107497328 @default.
- W2407144023 cites W2107742907 @default.
- W2407144023 cites W2108305553 @default.
- W2407144023 cites W2109241488 @default.
- W2407144023 cites W2115168896 @default.
- W2407144023 cites W2116357754 @default.
- W2407144023 cites W2121779716 @default.
- W2407144023 cites W2121963977 @default.
- W2407144023 cites W2126924389 @default.
- W2407144023 cites W2132430755 @default.
- W2407144023 cites W2132488072 @default.