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- W2407167554 abstract "Mycobacteria display pro- and anti-inflammatory effects in human and experimental pathology. We show here that both effects are mediated by Toll-like receptor 2 (Tlr2), by exploiting a previously characterized Tlr2 variant (Met82Ile). Tlr2 82ile promoted self-specific proinflammatory polarization as well as expansion of ag-specific FoxP3(+) Tregs, while Tlr2 82met impairs the expansion of Tregs and reduces the production of IFN-γ and IL-17 proinflammatory cytokines. Preferential dimerization with Tlr1 or Tlr6 could not explain these differences. In silico, we showed that Tlr2 variant Met82Ile modified the binding pocket for peptidoglycans and participated directly to a putative binding pocket for sugars and cadherins. The distinct pro- and anti-inflammatory actions impacted severity, extent of remission, and distribution of the lesions within the central nervous system of experimental autoimmune encephalomyelitis. Thus, Tlr2 has a janus function in vivo as mediator of the role of bacterial products in balancing pro- and anti-inflammatory immune responses." @default.
- W2407167554 created "2016-06-24" @default.
- W2407167554 creator A5003607573 @default.
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- W2407167554 date "2016-05-24" @default.
- W2407167554 modified "2023-10-14" @default.
- W2407167554 title "Toll-Like Receptor 2 Mediates In Vivo Pro- and Anti-inflammatory Effects of Mycobacterium Tuberculosis and Modulates Autoimmune Encephalomyelitis" @default.
- W2407167554 cites W120897673 @default.
- W2407167554 cites W1525680491 @default.
- W2407167554 cites W1577354978 @default.
- W2407167554 cites W1584119939 @default.
- W2407167554 cites W1586897675 @default.
- W2407167554 cites W1619327403 @default.
- W2407167554 cites W1787550163 @default.
- W2407167554 cites W1789772972 @default.
- W2407167554 cites W1963588217 @default.
- W2407167554 cites W1963843864 @default.
- W2407167554 cites W1965840687 @default.
- W2407167554 cites W1965872454 @default.
- W2407167554 cites W1966226308 @default.
- W2407167554 cites W1966430854 @default.
- W2407167554 cites W1970726284 @default.
- W2407167554 cites W1984736563 @default.
- W2407167554 cites W1987134040 @default.
- W2407167554 cites W1988995007 @default.
- W2407167554 cites W1993662841 @default.
- W2407167554 cites W1994624777 @default.
- W2407167554 cites W1998250187 @default.
- W2407167554 cites W2002062086 @default.
- W2407167554 cites W2008477650 @default.
- W2407167554 cites W2011221344 @default.
- W2407167554 cites W2014840359 @default.
- W2407167554 cites W2017893786 @default.
- W2407167554 cites W2025617940 @default.
- W2407167554 cites W2029667189 @default.
- W2407167554 cites W2031142437 @default.
- W2407167554 cites W2039839084 @default.
- W2407167554 cites W2041482977 @default.
- W2407167554 cites W2044757050 @default.
- W2407167554 cites W2046451999 @default.
- W2407167554 cites W2048417796 @default.
- W2407167554 cites W2049449911 @default.
- W2407167554 cites W2049886038 @default.
- W2407167554 cites W2050516476 @default.
- W2407167554 cites W2051728692 @default.
- W2407167554 cites W2061467646 @default.
- W2407167554 cites W2065746709 @default.
- W2407167554 cites W2079436480 @default.
- W2407167554 cites W2079714506 @default.
- W2407167554 cites W208059754 @default.
- W2407167554 cites W2094458576 @default.
- W2407167554 cites W2096618637 @default.
- W2407167554 cites W2100568625 @default.
- W2407167554 cites W2102143593 @default.
- W2407167554 cites W2103516815 @default.
- W2407167554 cites W2103704908 @default.
- W2407167554 cites W2104812418 @default.
- W2407167554 cites W2105442968 @default.
- W2407167554 cites W2107277218 @default.
- W2407167554 cites W2110768898 @default.
- W2407167554 cites W2112078889 @default.
- W2407167554 cites W2114783676 @default.
- W2407167554 cites W2115271898 @default.
- W2407167554 cites W2127821584 @default.
- W2407167554 cites W2131367762 @default.
- W2407167554 cites W2132675332 @default.
- W2407167554 cites W2133449490 @default.
- W2407167554 cites W2139113477 @default.
- W2407167554 cites W2140387095 @default.
- W2407167554 cites W2141515520 @default.
- W2407167554 cites W2141976216 @default.
- W2407167554 cites W2144448602 @default.
- W2407167554 cites W2146204398 @default.
- W2407167554 cites W2149788487 @default.
- W2407167554 cites W2153838990 @default.
- W2407167554 cites W2154915448 @default.
- W2407167554 cites W2156414024 @default.
- W2407167554 cites W2164820539 @default.
- W2407167554 cites W2167450603 @default.
- W2407167554 cites W2167504975 @default.
- W2407167554 cites W2170989872 @default.
- W2407167554 cites W2171645787 @default.
- W2407167554 cites W2173950467 @default.
- W2407167554 cites W2192080449 @default.
- W2407167554 cites W2240676980 @default.
- W2407167554 cites W2298051754 @default.
- W2407167554 cites W2413233050 @default.
- W2407167554 doi "https://doi.org/10.3389/fimmu.2016.00191" @default.
- W2407167554 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4878199" @default.