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- W2407171605 abstract "The tissue-specific Wilms' tumor gene WT1 is expressed in a range of acute leukemias and hematopoietic cell lines. Using single-strand conformational polymorphism analysis, we have found mutations in the WT1 gene in 4 of 36 acute leukemias. WT1 mutations are found in 15% of cases of acute myeloid leukemia, in which they are associated with a poor response to chemotherapy. The mutations comprise small insertions in exons 1 and 7 and a nonsense mutation in exon 9. All are predicted to produce a truncated WT1 protein with absence or disruption of the zinc finger region. These are the first mutations in the WT1 gene to be described in sporadic leukemia." @default.
- W2407171605 created "2016-06-24" @default.
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- W2407171605 date "1996-03-15" @default.
- W2407171605 modified "2023-10-05" @default.
- W2407171605 title "Mutations in the Wilms' tumor gene WT1 in leukemias" @default.
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- W2407171605 doi "https://doi.org/10.1182/blood.v87.6.2171.bloodjournal8762171" @default.
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