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- W2407222510 abstract "As a unique endogenous opioid ligand, dynorphin A shows paradoxical neuroexcitatory effects at bradykinin receptors, and the effects are known to be amplified by the upregulation of dynorphin A under chronic pain and inflammatory conditions. In our earlier structure-activity relationship studies, the amphipathic dynorphin A fragment, [Des-Arg(7) ]-Dyn A-(4-11), was identified as a pharmacophore for the bradykinin receptors along with key structural features. Here, further modifications of the pharmacophore showed that the position of a Pro residue is also an important feature because of its role in making (or disrupting) a β-turn or 310 helix structure which is crucial for receptor recognition." @default.
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- W2407222510 date "2016-06-06" @default.
- W2407222510 modified "2023-10-12" @default.
- W2407222510 title "Various modifications of the amphipathic dynorphin A pharmacophore for rat brain bradykinin receptors" @default.
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- W2407222510 doi "https://doi.org/10.1111/cbdd.12789" @default.
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