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• W2407281442 startingPage "e0145531" @default.
• W2407281442 abstract "Peg3 is an imprinted gene that is predicted to encode a DNA-binding zinc finger protein. This was previously demonstrated through Chromatin ImmunoPrecipitation-based Sequencing experiments. In the current study, we reanalyzed the previous ChIP-Seq results and further characterized the DNA-binding motif of PEG3. According to the results, PEG3 binds to the promoters and enhancers of a subset of genes that are closely associated with the known functions of Peg3. Some of these identified targets include Tufm, Mrpl45, Cry2, Per1, Slc25a29 and Slc38a2. With this set of targets, we derived a DNA-binding motif of PEG3, 5’-GTGGCAGT-3’, which also provides a tabulated matrix that can be used for predicting other unknown genomic targets. Among the newly identified targets, we analyzed in detail the two loci, Slc38a2 and Slc38a4, which are known to be involved in neutral amino acid transport. The results indicated that PEG3 likely functions as a transcriptional repressor for these two loci. Overall, the current study provides a set of genomic targets and also redefines the DNA-binding motif for the imprinted transcription factor PEG3." @default.
• W2407281442 created "2016-06-24" @default.
• W2407281442 creator A5038218102 @default.
• W2407281442 creator A5044936635 @default.
• W2407281442 creator A5071137239 @default.
• W2407281442 date "2015-12-21" @default.
• W2407281442 modified "2023-10-15" @default.
• W2407281442 title "DNA-Binding Motif of the Imprinted Transcription Factor PEG3" @default.
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• W2407281442 doi "https://doi.org/10.1371/journal.pone.0145531" @default.
• W2407281442 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4686966" @default.
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