FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2407368622> ?p ?o ?g. }

• W2407368622 endingPage "1430" @default.
• W2407368622 startingPage "1424" @default.
• W2407368622 abstract "OBJECTIVE To evaluate whether low HDL cholesterol (HDL-c) levels are a risk factor for cardiovascular disease and mortality in patients with type 2 diabetes and whether it remains a residual risk factor when attaining low LDL cholesterol (LDL-c) treatment goals or when LDL-c is treated with intensive lipid-lowering therapy. RESEARCH DESIGN AND METHODS We performed a prospective cohort study of 1,829 patients with type 2 diabetes included in the Second Manifestations of ARTerial disease (SMART) cohort. Cox proportional hazard models were used to evaluate the risk of HDL-c on cardiovascular events and all-cause mortality. Analyses were performed in strata of LDL-c levels (&lt;2.0, 2.0–2.5, and &gt;2.5 mmol/L) and lipid-lowering therapy intensity and were adjusted for age, sex, BMI, smoking, alcohol, LDL-c, triglycerides, systolic blood pressure, estimated glomerular filtration rate, glucose, and HbA1c. RESULTS A total of 335 new cardiovascular events and 385 deaths occurred during a median follow-up of 7.0 years (interquartile range 3.9–10.4). No relation was found between plasma HDL-c and cardiovascular events (hazard ratio [HR] 0.97, 95% CI 0.93–1.01) or all-cause mortality (HR 0.99, 95% CI 0.96–1.03). Subgroup analysis supported effect modification by plasma LDL-c levels. In patients with LDL-c levels &lt;2.0 mmol/L, higher HDL-c was related to higher risk for all-cause mortality (HR 1.14, 95% CI 1.07–1.21). Higher HDL-c was also related to higher risk for cardiovascular events in patients with LDL-c levels &lt;2.0 mmol/L (HR 1.10, 95% CI 1.07–1.21) in contrast to patients with LDL-c levels between 2.0 and 2.5 mmol/L (HR 0.85, 95% CI 0.75–0.95) and &gt;2.5 mmol/L (HR 0.96, 95% CI 0.91–1.00). CONCLUSIONS In high-risk patients with type 2 diabetes with LDL-c levels &lt;2.0 mmol/L, higher HDL-c at baseline is unexpectedly related to a higher risk for cardiovascular events and all-cause mortality in contrast to high-risk patients with type 2 diabetes with LDL-c levels between 2.0 and 2.5 mmol/L." @default.
• W2407368622 created "2016-06-24" @default.
• W2407368622 creator A5014981482 @default.
• W2407368622 creator A5030455874 @default.
• W2407368622 creator A5032480026 @default.
• W2407368622 creator A5041498750 @default.
• W2407368622 creator A5077863525 @default.
• W2407368622 creator A5082338532 @default.
• W2407368622 date "2016-05-23" @default.
• W2407368622 modified "2023-10-16" @default.
• W2407368622 title "HDL Cholesterol as a Residual Risk Factor for Vascular Events and All-Cause Mortality in Patients With Type 2 Diabetes" @default.
• W2407368622 cites W1551234954 @default.
• W2407368622 cites W1735246829 @default.
• W2407368622 cites W1856460279 @default.
• W2407368622 cites W1972661406 @default.
• W2407368622 cites W1980243442 @default.
• W2407368622 cites W1982485566 @default.
• W2407368622 cites W1985794857 @default.
• W2407368622 cites W1993761643 @default.
• W2407368622 cites W2007839248 @default.
• W2407368622 cites W2019071303 @default.
• W2407368622 cites W2035566219 @default.
• W2407368622 cites W2058610272 @default.
• W2407368622 cites W2059743234 @default.
• W2407368622 cites W2077876793 @default.
• W2407368622 cites W2088137077 @default.
• W2407368622 cites W2102941237 @default.
• W2407368622 cites W2107295258 @default.
• W2407368622 cites W2110437194 @default.
• W2407368622 cites W2118825330 @default.
• W2407368622 cites W2123926109 @default.
• W2407368622 cites W2140995117 @default.
• W2407368622 cites W2158057499 @default.
• W2407368622 cites W2164324917 @default.
• W2407368622 cites W2198678228 @default.
• W2407368622 cites W2315575691 @default.
• W2407368622 cites W4238251256 @default.
• W2407368622 cites W4244540230 @default.
• W2407368622 cites W49042913 @default.
• W2407368622 doi "https://doi.org/10.2337/dc16-0155" @default.
• W2407368622 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27222511" @default.
• W2407368622 hasPublicationYear "2016" @default.
• W2407368622 type Work @default.
• W2407368622 sameAs 2407368622 @default.
• W2407368622 citedByCount "27" @default.
• W2407368622 countsByYear W24073686222016 @default.
• W2407368622 countsByYear W24073686222017 @default.
• W2407368622 countsByYear W24073686222018 @default.
• W2407368622 countsByYear W24073686222019 @default.
• W2407368622 countsByYear W24073686222020 @default.
• W2407368622 countsByYear W24073686222021 @default.
• W2407368622 countsByYear W24073686222022 @default.
• W2407368622 countsByYear W24073686222023 @default.
• W2407368622 crossrefType "journal-article" @default.
• W2407368622 hasAuthorship W2407368622A5014981482 @default.
• W2407368622 hasAuthorship W2407368622A5030455874 @default.
• W2407368622 hasAuthorship W2407368622A5032480026 @default.
• W2407368622 hasAuthorship W2407368622A5041498750 @default.
• W2407368622 hasAuthorship W2407368622A5077863525 @default.
• W2407368622 hasAuthorship W2407368622A5082338532 @default.
• W2407368622 hasBestOaLocation W24073686221 @default.
• W2407368622 hasConcept C119060515 @default.
• W2407368622 hasConcept C126322002 @default.
• W2407368622 hasConcept C134018914 @default.
• W2407368622 hasConcept C152163801 @default.
• W2407368622 hasConcept C164705383 @default.
• W2407368622 hasConcept C188816634 @default.
• W2407368622 hasConcept C201903717 @default.
• W2407368622 hasConcept C207103383 @default.
• W2407368622 hasConcept C2777180221 @default.
• W2407368622 hasConcept C2778163477 @default.
• W2407368622 hasConcept C44249647 @default.
• W2407368622 hasConcept C50382708 @default.
• W2407368622 hasConcept C50440223 @default.
• W2407368622 hasConcept C555293320 @default.
• W2407368622 hasConcept C71924100 @default.
• W2407368622 hasConcept C84393581 @default.
• W2407368622 hasConcept C90924648 @default.
• W2407368622 hasConceptScore W2407368622C119060515 @default.
• W2407368622 hasConceptScore W2407368622C126322002 @default.
• W2407368622 hasConceptScore W2407368622C134018914 @default.
• W2407368622 hasConceptScore W2407368622C152163801 @default.
• W2407368622 hasConceptScore W2407368622C164705383 @default.
• W2407368622 hasConceptScore W2407368622C188816634 @default.
• W2407368622 hasConceptScore W2407368622C201903717 @default.
• W2407368622 hasConceptScore W2407368622C207103383 @default.
• W2407368622 hasConceptScore W2407368622C2777180221 @default.
• W2407368622 hasConceptScore W2407368622C2778163477 @default.
• W2407368622 hasConceptScore W2407368622C44249647 @default.
• W2407368622 hasConceptScore W2407368622C50382708 @default.
• W2407368622 hasConceptScore W2407368622C50440223 @default.
• W2407368622 hasConceptScore W2407368622C555293320 @default.
• W2407368622 hasConceptScore W2407368622C71924100 @default.
• W2407368622 hasConceptScore W2407368622C84393581 @default.
• W2407368622 hasConceptScore W2407368622C90924648 @default.
• W2407368622 hasIssue "8" @default.
• W2407368622 hasLocation W24073686221 @default.
• W2407368622 hasLocation W24073686222 @default.

• next